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Altered medial temporal activation related to local glutamate levels in subjects with prodromal signs of psychosis.


Valli, I; Stone, J; Mechelli, A; Bhattacharyya, S; Raffin, M; Allen, P; Fusar-Poli, P; Lythgoe, D; O'Gorman, R; Seal, M; McGuire, P (2011). Altered medial temporal activation related to local glutamate levels in subjects with prodromal signs of psychosis. Biological Psychiatry, 69(1):97-9.

Abstract

In individuals at high risk of psychosis, medial temporal dysfunction seemed related to a loss of the normal relationship with local glutamate levels. This study provides the first evidence that links medial temporal dysfunction with the central glutamate system in humans and is consistent with evidence that drugs that modulate glutamatergic transmission might be useful in the treatment of psychosis.

Abstract

In individuals at high risk of psychosis, medial temporal dysfunction seemed related to a loss of the normal relationship with local glutamate levels. This study provides the first evidence that links medial temporal dysfunction with the central glutamate system in humans and is consistent with evidence that drugs that modulate glutamatergic transmission might be useful in the treatment of psychosis.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:22 Feb 2012 15:19
Last Modified:05 Apr 2016 15:25
Publisher:Elsevier
ISSN:0006-3223
Publisher DOI:https://doi.org/10.1016/j.biopsych.2010.08.033
PubMed ID:21035785

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