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Transformation of stimulus value signals into motor commands during simple choice


Hare, Todd A; Schultz, Wolfram; Camerer, Colin F; O'Doherty, John P; Rangel, Antonio (2011). Transformation of stimulus value signals into motor commands during simple choice. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 108(44):18120-18125.

Abstract

Decision-making can be broken down into several component processes: assigning values to stimuli under consideration, selecting an option by comparing those values, and initiating motor responses to obtain the reward. Although much is known about the neural encoding of stimulus values and motor commands, little is known about the mechanisms through which stimulus values are compared, and the resulting decision is transmitted to motor systems. We investigated this process using human fMRI in a task where choices were indicated using the left or right hand. We found evidence consistent with the hypothesis that value signals are computed in the ventral medial prefrontal cortex, they are passed to regions of dorsomedial prefrontal cortex and intraparietal sulcus, implementing a comparison process, and the output of the comparator regions modulates activity in motor cortex to implement the choice. These results describe the network through which stimulus values are transformed into actions during a simple choice task.

Abstract

Decision-making can be broken down into several component processes: assigning values to stimuli under consideration, selecting an option by comparing those values, and initiating motor responses to obtain the reward. Although much is known about the neural encoding of stimulus values and motor commands, little is known about the mechanisms through which stimulus values are compared, and the resulting decision is transmitted to motor systems. We investigated this process using human fMRI in a task where choices were indicated using the left or right hand. We found evidence consistent with the hypothesis that value signals are computed in the ventral medial prefrontal cortex, they are passed to regions of dorsomedial prefrontal cortex and intraparietal sulcus, implementing a comparison process, and the output of the comparator regions modulates activity in motor cortex to implement the choice. These results describe the network through which stimulus values are transformed into actions during a simple choice task.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:03 Faculty of Economics > Department of Economics
Dewey Decimal Classification:330 Economics
Language:English
Date:1 November 2011
Deposited On:18 Jan 2012 15:14
Last Modified:01 May 2016 07:40
Publisher:National Academy of Sciences
ISSN:0027-8424
Free access at:Related URL. An embargo period may apply.
Publisher DOI:https://doi.org/10.1073/pnas.1109322108
Official URL:http://www.pnas.org/content/108/44/18120
Related URLs:http://www.rnl.caltech.edu/publications/pdf/hare2011b.pdf

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