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Paraneoplastic hyperthyroidism


Kohler, S; Tschopp, O; Jacky, E; Schmid, C (2011). Paraneoplastic hyperthyroidism. BMJ Case Reports, 2011:bcr0420114163.

Abstract

The authors describe a 31-year-old male with a metastatic germ cell tumour and massively elevated human chorionic gonadotrophin (HCG)
levels who presented with hyperthyroidism. As HCG is structurally closely related to thyroid stimulating hormone (TSH), it can activate the TSH
receptor; grossly elevated levels may result in hyperthyroidism. After initiation of chemotherapy, HCG levels decreased and hyperthyroidism
resolved.

Abstract

The authors describe a 31-year-old male with a metastatic germ cell tumour and massively elevated human chorionic gonadotrophin (HCG)
levels who presented with hyperthyroidism. As HCG is structurally closely related to thyroid stimulating hormone (TSH), it can activate the TSH
receptor; grossly elevated levels may result in hyperthyroidism. After initiation of chemotherapy, HCG levels decreased and hyperthyroidism
resolved.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Endocrinology and Diabetology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:24 Jan 2012 14:39
Last Modified:05 Apr 2016 15:28
Publisher:BMJ Publishing Group
ISSN:1757-790X
Publisher DOI:https://doi.org/10.1136/bcr.04.2011.4163

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