Header

UZH-Logo

Maintenance Infos

Sensorimotor gating of schizophrenia patients depends on catechol O-methyltransferase Val158Met polymorphism


Quednow, Boris B; Wagner, M; Mössner, R; Maier, W; Kühn, K U (2010). Sensorimotor gating of schizophrenia patients depends on catechol O-methyltransferase Val158Met polymorphism. Schizophrenia Bulletin, 36(2):341-346.

Abstract

It has been recently shown that Catechol O-methyltransferase (COMT) Val(158)Met polymorphism strongly influences prepulse inhibition (PPI) of the acoustic startle response (ASR) in healthy human volunteers. Given that schizophrenia patients exhibit impairment in PPI and that COMT is a putative susceptibility gene for schizophrenia, we investigated the impact of the COMT Val(158)Met polymorphisms on PPI in schizophrenic inpatients. We analyzed COMT Val(158)Met polymorphisms and assessed startle reactivity, habituation, and PPI of ASR in 68 Caucasian schizophrenia inpatients. Clinical symptoms were measured with the Positive and Negative Syndrome Scale (PANSS). Patients carrying the Val(158)Met Met/Met allele showed elevated PPI levels whereas startle reactivity and habituation did not differ from the other two genotypes. These preliminary results imply that PPI is influenced by COMT Val(158)Met genotype in schizophrenia as well. In concert with other findings, our data suggest that PPI is a polygenic trait.

Abstract

It has been recently shown that Catechol O-methyltransferase (COMT) Val(158)Met polymorphism strongly influences prepulse inhibition (PPI) of the acoustic startle response (ASR) in healthy human volunteers. Given that schizophrenia patients exhibit impairment in PPI and that COMT is a putative susceptibility gene for schizophrenia, we investigated the impact of the COMT Val(158)Met polymorphisms on PPI in schizophrenic inpatients. We analyzed COMT Val(158)Met polymorphisms and assessed startle reactivity, habituation, and PPI of ASR in 68 Caucasian schizophrenia inpatients. Clinical symptoms were measured with the Positive and Negative Syndrome Scale (PANSS). Patients carrying the Val(158)Met Met/Met allele showed elevated PPI levels whereas startle reactivity and habituation did not differ from the other two genotypes. These preliminary results imply that PPI is influenced by COMT Val(158)Met genotype in schizophrenia as well. In concert with other findings, our data suggest that PPI is a polygenic trait.

Statistics

Citations

25 citations in Web of Science®
38 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

248 downloads since deposited on 20 Nov 2008
37 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:March 2010
Deposited On:20 Nov 2008 14:44
Last Modified:03 Nov 2017 08:39
Publisher:Oxford University Press
ISSN:0586-7614
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/schbul/sbn088
PubMed ID:18635674

Download

Download PDF  'Sensorimotor gating of schizophrenia patients depends on catechol O-methyltransferase Val158Met polymorphism'.
Preview
Content: Accepted Version
Filetype: PDF
Size: 1MB
View at publisher
Download PDF  'Sensorimotor gating of schizophrenia patients depends on catechol O-methyltransferase Val158Met polymorphism'.
Preview
Filetype: PDF
Size: 1MB