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Stimulus-induced, sleep-bound, focal seizures: a case report


Siclari, F; Nobili, L; Lo Russo, G; Moscato, A; Buck, A; Bassetti, C L; Khatami, R (2011). Stimulus-induced, sleep-bound, focal seizures: a case report. Sleep, 34(12):1727-1730.

Abstract

STUDY OBJECTIVES:

In nocturnal frontal lobe epilepsy (NFLE), seizures occur almost exclusively during NREM sleep. Why precisely these seizures are sleep-bound remains unknown. Studies of patients with nonlesional familial forms of NFLE have suggested the arousal system may play a major role in their pathogenesis. We report the case of a patient with pharmaco-resistant, probably cryptogenic form of non-familial NFLE and strictly sleep-bound seizures that could be elicited by alerting stimuli and were associated with ictal bilateral thalamic and right orbital-insular hyperperfusion on SPECT imaging.

Abstract

STUDY OBJECTIVES:

In nocturnal frontal lobe epilepsy (NFLE), seizures occur almost exclusively during NREM sleep. Why precisely these seizures are sleep-bound remains unknown. Studies of patients with nonlesional familial forms of NFLE have suggested the arousal system may play a major role in their pathogenesis. We report the case of a patient with pharmaco-resistant, probably cryptogenic form of non-familial NFLE and strictly sleep-bound seizures that could be elicited by alerting stimuli and were associated with ictal bilateral thalamic and right orbital-insular hyperperfusion on SPECT imaging.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:30 Jan 2012 08:32
Last Modified:05 Apr 2016 15:31
Publisher:Associated Professional Sleep Societies, LLC
ISSN:0161-8105
Publisher DOI:https://doi.org/10.5665/sleep.1448
PubMed ID:22131612

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