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Behandlung einer chronischen Kupfervergiftung mit oralem Ammoniummolybdat und Natriumsulfat bei Milchschafen


Kupper, J; Bidaut, A; Waldvogel, A; Emmenegger, B; Naegeli, H (2005). Behandlung einer chronischen Kupfervergiftung mit oralem Ammoniummolybdat und Natriumsulfat bei Milchschafen. Schweizer Archiv für Tierheilkunde, 147(5):219-224.

Abstract

Four weeks after the introduction of a new ration, a herd of sheep in the Swiss midland area was affected by depression, anorexia, decreased milk production, anemia, hemoglobinuria and frequent recumbency. Seventeen ewes died within a few days. A diagnosis of chronic copper poisoning was based on the results of feed analysis, histopathological findings and the toxicological examination of liver tissue. The remaining sheep were treated with oral ammonium molybdate and sodium sulfate, which together provide an inexpensive alternative to the chelator D-penicillamine.This combination not only prevents further copper intake, but also supports its elimination from the hepatocellular storage compartments. Serum copper levels have been determined to monitor the mobilization of copper following this antidote therapy.

Abstract

Four weeks after the introduction of a new ration, a herd of sheep in the Swiss midland area was affected by depression, anorexia, decreased milk production, anemia, hemoglobinuria and frequent recumbency. Seventeen ewes died within a few days. A diagnosis of chronic copper poisoning was based on the results of feed analysis, histopathological findings and the toxicological examination of liver tissue. The remaining sheep were treated with oral ammonium molybdate and sodium sulfate, which together provide an inexpensive alternative to the chelator D-penicillamine.This combination not only prevents further copper intake, but also supports its elimination from the hepatocellular storage compartments. Serum copper levels have been determined to monitor the mobilization of copper following this antidote therapy.

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Additional indexing

Other titles:Treatment of chronic copper poisoning with oral application of ammonium molybdate and natrium sulphate in milk sheep
Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
Language:German
Date:May 2005
Deposited On:27 Mar 2009 14:22
Last Modified:05 Apr 2016 12:35
Publisher:Hans Huber
ISSN:0036-7281
Publisher DOI:https://doi.org/10.1024/0036-7281.147.5.219
PubMed ID:15929603

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