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Genetic and clinical characteristics of Moyamoya disease in Europeans


Krischek, B; Kasuya, H; Khan, N; Tatagiba, M; Roder, C; Kraemer, M (2011). Genetic and clinical characteristics of Moyamoya disease in Europeans. Acta Neurochirurgica Supplementum, 112(2):31-34.

Abstract

The European form of Moyamoya disease clearly differs from the Asian form. Clinically the timing of vasculopathy onset and a lower rate of hemorrhage are striking as compared to the Asian Moyamoya disease.Single nucleotide polymorphisms that play a role in atherosclerosis, vascular growth and transformation processes have been found to be associated with the European form. Candidate gene associations found in Asian patients could not be replicated in European patients.To elucidate the characteristics, we describe the clinical features as well as the genetic findings that we have found in our combined cohorts of European patients.

Abstract

The European form of Moyamoya disease clearly differs from the Asian form. Clinically the timing of vasculopathy onset and a lower rate of hemorrhage are striking as compared to the Asian Moyamoya disease.Single nucleotide polymorphisms that play a role in atherosclerosis, vascular growth and transformation processes have been found to be associated with the European form. Candidate gene associations found in Asian patients could not be replicated in European patients.To elucidate the characteristics, we describe the clinical features as well as the genetic findings that we have found in our combined cohorts of European patients.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Clinic for Surgery
Dewey Decimal Classification:610 Medicine & health
Date:2011
Deposited On:24 Feb 2012 15:51
Last Modified:05 Apr 2016 15:32
Publisher:Springer
ISSN:0065-1419
Publisher DOI:https://doi.org/10.1007/978-3-7091-0661-7_6
PubMed ID:21691984

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