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Another facet of ubiquitylation: death


Wong, W Wei-Lynn; Silke, John (2009). Another facet of ubiquitylation: death. Journal of Molecular Cell Biology, 1(2):80-81.

Abstract

Ubiquitylation of caspase-8 by the Cullin3 E3 ligase allows its translocation to cytosolic aggregates in the cell by p62/sequesto- some-1, increasing caspase-8 activation and thus leading to TRAIL-induced cell death.

Abstract

Ubiquitylation of caspase-8 by the Cullin3 E3 ligase allows its translocation to cytosolic aggregates in the cell by p62/sequesto- some-1, increasing caspase-8 activation and thus leading to TRAIL-induced cell death.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2009
Deposited On:15 Jun 2012 15:35
Last Modified:05 Apr 2016 15:33
Publisher:Oxford University Press
ISSN:1759-4685
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/jmcb/mjp019
PubMed ID:19797318

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