Header

UZH-Logo

Maintenance Infos

Clinical and dermoscopic characteristics of amelanotic melanomas that are not of the nodular subtype


Jaimes, N; Braun, R P; Thomas, L; Marghoob, A A (2012). Clinical and dermoscopic characteristics of amelanotic melanomas that are not of the nodular subtype. Journal of the European Academy of Dermatology and Venereology, 26(5):591-596.

Abstract

Background:  Amelanotic melanomas remain challenging to diagnose. Objective:  To analyze and describe the clinical and dermoscopic characteristics of amelanotic melanomas that are not of the nodular subtype. Patients/Methods:  We conducted a retrospective review of 20 consecutively diagnosed amelanotic melanomas. The clinical and dermoscopic images of pathologically confirmed amelanotic melanomas that were not of the nodular subtype were analyzed. In addition, the clinical diagnosis and the reasons why these lesions were biopsied were examined. Results: All 20 amelanotic melanomas were erythematous and lacked any of the clinical ABCD features commonly attributed to melanoma. The lesions appeared clinically to be relatively symmetric with regular borders and manifesting a circular to oval morphology. Dermoscopically, all lesions manifested polymorphous vascular pattern. Conclusions:  Amelanotic melanomas that are not of the nodular subtype often present as clinically symmetric erythematous lesions. Therefore, it is important to consider AMs in the differential diagnosis of isolated and persistent erythematous outlier lesions, even if they are symmetric in appearance. Additionally, the presence of a polymorphous vascular pattern seen with dermoscopy can facilitate in correctly identifying these melanomas.

Abstract

Background:  Amelanotic melanomas remain challenging to diagnose. Objective:  To analyze and describe the clinical and dermoscopic characteristics of amelanotic melanomas that are not of the nodular subtype. Patients/Methods:  We conducted a retrospective review of 20 consecutively diagnosed amelanotic melanomas. The clinical and dermoscopic images of pathologically confirmed amelanotic melanomas that were not of the nodular subtype were analyzed. In addition, the clinical diagnosis and the reasons why these lesions were biopsied were examined. Results: All 20 amelanotic melanomas were erythematous and lacked any of the clinical ABCD features commonly attributed to melanoma. The lesions appeared clinically to be relatively symmetric with regular borders and manifesting a circular to oval morphology. Dermoscopically, all lesions manifested polymorphous vascular pattern. Conclusions:  Amelanotic melanomas that are not of the nodular subtype often present as clinically symmetric erythematous lesions. Therefore, it is important to consider AMs in the differential diagnosis of isolated and persistent erythematous outlier lesions, even if they are symmetric in appearance. Additionally, the presence of a polymorphous vascular pattern seen with dermoscopy can facilitate in correctly identifying these melanomas.

Statistics

Citations

19 citations in Web of Science®
25 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

1 download since deposited on 12 Feb 2012
0 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:12 Feb 2012 10:32
Last Modified:07 Dec 2017 12:14
Publisher:Blackwell
ISSN:0926-9959 (P) 1468-3083 (E)
Publisher DOI:https://doi.org/10.1111/j.1468-3083.2011.04122.x
PubMed ID:21585561

Download