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Disseminated molluscum contagiosum in a HIV-positive child. Improvement after therapy with 5% imiquimod


Theiler, M; Kempf, W; Kerl, K; French, L E; Hofbauer, G F L (2011). Disseminated molluscum contagiosum in a HIV-positive child. Improvement after therapy with 5% imiquimod. Journal of Dermatological Case Reports, 5(2):19-23.

Abstract

BACKGROUND:

Molluscum contagiosum (MC) is a frequent and usually benign cutaneous infection with molluscum contagiosum virus (MCV), affecting mainly children and young sexually active adults. With the emergence of HIV/AIDS, a new patient group at risk has been identified with often extensive skin involvement and recalcitrant disease.
MAIN OBSERVATIONS:

We report a case of a girl with connatal HIV-infection, suffering from extensive, disseminated MC. Due to multi-resistance, an effective antiretroviral therapy could not be established for years, rendering an effective treatment of MC by established treatment options virtually impossible. An off-label use of imiquimod showed a marked improvement of lesion counts in this patient, whereas a complete clearance could only be achieved once effective antiretroviral therapy was introduced.
CONCLUSIONS:

We believe that imiquimod may represent a valuable treatment option for molluscum contagiosum especially in the context of marked immunosuppression, where sensitive areas like the face and neck are often involved and scarring must be avoided.

Abstract

BACKGROUND:

Molluscum contagiosum (MC) is a frequent and usually benign cutaneous infection with molluscum contagiosum virus (MCV), affecting mainly children and young sexually active adults. With the emergence of HIV/AIDS, a new patient group at risk has been identified with often extensive skin involvement and recalcitrant disease.
MAIN OBSERVATIONS:

We report a case of a girl with connatal HIV-infection, suffering from extensive, disseminated MC. Due to multi-resistance, an effective antiretroviral therapy could not be established for years, rendering an effective treatment of MC by established treatment options virtually impossible. An off-label use of imiquimod showed a marked improvement of lesion counts in this patient, whereas a complete clearance could only be achieved once effective antiretroviral therapy was introduced.
CONCLUSIONS:

We believe that imiquimod may represent a valuable treatment option for molluscum contagiosum especially in the context of marked immunosuppression, where sensitive areas like the face and neck are often involved and scarring must be avoided.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:June 2011
Deposited On:12 Feb 2012 10:18
Last Modified:21 Nov 2017 15:52
Publisher:Spejaliści Dermatolodzy, PL
ISSN:1898-7249 (E)
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.3315/jdcr.2011.1066
PubMed ID:21894250

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