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Examination of the effect of acute levodopa administration on the loudness dependence of auditory evoked potentials (LDAEP) in humans


Hitz, K; Heekeren, K; Obermann, C; Huber, T; Juckel, G; Kawohl, W (2012). Examination of the effect of acute levodopa administration on the loudness dependence of auditory evoked potentials (LDAEP) in humans. Psychopharmacology, 221(3):389-396.

Abstract

RATIONALE:

The loudness dependence of the auditory evoked potential (LDAEP) is considered a noninvasive in vivo marker of central serotonergic functioning in humans. Nevertheless, results of genetic association studies point towards a modulation of this biomarker by dopaminergic neurotransmission.
OBJECTIVE:

We examined the effect of dopaminergic modulation on the LDAEP using L-3,4-dihydroxyphenylalanine (levodopa)/benserazide (Madopar®) as a challenge agent in healthy volunteers.
METHODS:

A double-blind placebo-controlled challenge design was chosen. Forty-two healthy participants (21 females and 21 males) underwent two LDAEP measurements, following a baseline LDAEP measurement either placebo or levodopa (levodopa 200 mg/benserazide 50 mg) were given orally. Changes in the amplitude and dipole source activity of the N1/P2 intensities (60, 70, 80, 90, and 100 dB) were analyzed.
RESULTS:

The participants of neither the levodopa nor the placebo group showed any significant LDAEP alterations compared to the baseline measurement. The test-retest reliability (Cronbachs Alpha) between baseline and intervention was 0.966 in the verum group and 0.759 in the placebo group, respectively.
CONCLUSIONS:

The administration of levodopa showed no effect on the LDAEP. These findings are in line with other trials using dopamine receptor agonists.

Abstract

RATIONALE:

The loudness dependence of the auditory evoked potential (LDAEP) is considered a noninvasive in vivo marker of central serotonergic functioning in humans. Nevertheless, results of genetic association studies point towards a modulation of this biomarker by dopaminergic neurotransmission.
OBJECTIVE:

We examined the effect of dopaminergic modulation on the LDAEP using L-3,4-dihydroxyphenylalanine (levodopa)/benserazide (Madopar®) as a challenge agent in healthy volunteers.
METHODS:

A double-blind placebo-controlled challenge design was chosen. Forty-two healthy participants (21 females and 21 males) underwent two LDAEP measurements, following a baseline LDAEP measurement either placebo or levodopa (levodopa 200 mg/benserazide 50 mg) were given orally. Changes in the amplitude and dipole source activity of the N1/P2 intensities (60, 70, 80, 90, and 100 dB) were analyzed.
RESULTS:

The participants of neither the levodopa nor the placebo group showed any significant LDAEP alterations compared to the baseline measurement. The test-retest reliability (Cronbachs Alpha) between baseline and intervention was 0.966 in the verum group and 0.759 in the placebo group, respectively.
CONCLUSIONS:

The administration of levodopa showed no effect on the LDAEP. These findings are in line with other trials using dopamine receptor agonists.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Clinical and Social Psychiatry Zurich West (former)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:09 Mar 2012 13:50
Last Modified:05 Apr 2016 15:34
Publisher:Springer
ISSN:0033-3158
Publisher DOI:https://doi.org/10.1007/s00213-011-2586-8
PubMed ID:22119935

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