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Effects of meal consistency and ingested fluid volume on the intragastric distribution of a drug model in humans - a magnetic resonance imaging study


Faas, H; Steingoetter, A; Feinle, C; Rades, T; Lengsfeld, H; Boesiger, P; Fried, M; Schwizer, W (2002). Effects of meal consistency and ingested fluid volume on the intragastric distribution of a drug model in humans - a magnetic resonance imaging study. Alimentary Pharmacology & Therapeutics, 16(2):217-224.

Abstract

The intragastric distribution kinetics of the marker gadolinium tetra-azacyclododecane tetra-acetic acid appeared to depend on meal consistency, but not on the amount of water co-ingested. Three-dimensional magnetic resonance imaging allows detailed analysis of the intragastric distribution of a drug model in relation to meal emptying and intragastric meal distribution.

Abstract

The intragastric distribution kinetics of the marker gadolinium tetra-azacyclododecane tetra-acetic acid appeared to depend on meal consistency, but not on the amount of water co-ingested. Three-dimensional magnetic resonance imaging allows detailed analysis of the intragastric distribution of a drug model in relation to meal emptying and intragastric meal distribution.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Gastroenterology and Hepatology
04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Language:English
Date:2002
Deposited On:19 Mar 2014 13:30
Last Modified:22 Nov 2017 12:49
Publisher:Wiley-Blackwell
ISSN:0269-2813
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1046/j.1365-2036.2002.01154.x
PubMed ID:11860404

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