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Manjak vitamina B12 u djece - podcijenjena opasnost u svjetlu spoznaja


Juras, K; Fumić, K; Izaković, S; Puseljić, S; Culić, V; Galić, S; Buljević, A D; Benjak, V; Colić, A; Frković, S H; Maradin, M; Sarnavka, V; Bilić, K; Baumgartner, M; Barić, I (2011). Manjak vitamina B12 u djece - podcijenjena opasnost u svjetlu spoznaja. Lijec̆nic̆ki vjesnik, 133(1-2):39-50.

Abstract

Vitamin B12 (cobalamin) has two active forms, adenosylcobalamin and methylcobalamin which have a key role in two important metabolic pathways in humans and their deficiency is responsible for clinical problems. Cobalamin is essential during whole life, but its sufficient amount is extra important in fetal and neonatal period, when it is essential for normal child growth and development as well as for normal development of the central nervous system. Because of very complex transport and metabolism, its deficiency can be manifested in numerous congenital and acquired disorders. Vitamin B12 deficiency mostly has non-specific clinical features, it carries a great risk of permanent consequences, but most frequently it is easily curable if diagnosed on time. In Croatia cobalamin deficiency in children has been diagnosed too rarely. Accordingly, the aim of this paper is to point to the recently gained knowledge on cobalamin metabolism, present typical case reports and to provide guidelines for rapid and proper diagnostic and therapeutic approach.

Abstract

Vitamin B12 (cobalamin) has two active forms, adenosylcobalamin and methylcobalamin which have a key role in two important metabolic pathways in humans and their deficiency is responsible for clinical problems. Cobalamin is essential during whole life, but its sufficient amount is extra important in fetal and neonatal period, when it is essential for normal child growth and development as well as for normal development of the central nervous system. Because of very complex transport and metabolism, its deficiency can be manifested in numerous congenital and acquired disorders. Vitamin B12 deficiency mostly has non-specific clinical features, it carries a great risk of permanent consequences, but most frequently it is easily curable if diagnosed on time. In Croatia cobalamin deficiency in children has been diagnosed too rarely. Accordingly, the aim of this paper is to point to the recently gained knowledge on cobalamin metabolism, present typical case reports and to provide guidelines for rapid and proper diagnostic and therapeutic approach.

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Other titles:Vitamin B12 deficiency in children - underestimated danger in the light of new knowledge
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
04 Faculty of Medicine > Center for Integrative Human Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:January 2011
Deposited On:26 Feb 2012 10:43
Last Modified:07 Apr 2017 17:30
Publisher:Zbor Lijecnika Hrvatske
ISSN:0024-3477
Official URL:http://lijecnicki-vjesnik.hlz.hr/broj-1-2/273-manjak-vitamina-b12-u-djece--podcijenjena-opasnost-u-svjetlu-novih-spoznaja
PubMed ID:21644278

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