Header

UZH-Logo

Maintenance Infos

Treatment of vulvar Paget disease with topical imiquimod: a case report and review of the literature


Feldmeyer, L; Kerl, K; Kamarashev, J; de Viragh, P; French, L E (2011). Treatment of vulvar Paget disease with topical imiquimod: a case report and review of the literature. Journal of Dermatological Case Reports, 5(3):42-46.

Abstract

BACKGROUND:

Extramammary Paget's disease is a cutaneous neoplasm that presents as erythematous crusted patches and plaques reminiscent of contact dermatitis or inverse psoriasis that can be a challenge to treat in a tissue-sparing manner. The most commonly involved site for this rare disorder is the anogenital region. Surgery is considered as the gold standard therapy. In the last years, the topical use of imiquimod cream in the treatment of this condition has been reported.
MAIN OBSERVATIONS:

We present a case of a 59-year-old woman with primary extramammary Paget's disease of the vulva, in which a conservative approach to therapy was desired, and who underwent complete and stable remission with imiquimod cream. We also review the previous reports of patients with extramammary Paget's disease treated with imiquimod cream.
CONCLUSIONS:

Imiquimod therapy may be an alternative for primary as well as recurring extramammary Paget's disease. Treatment-associated morbidity is minimal compared with other therapies, such as surgery which may be debilitating.

Abstract

BACKGROUND:

Extramammary Paget's disease is a cutaneous neoplasm that presents as erythematous crusted patches and plaques reminiscent of contact dermatitis or inverse psoriasis that can be a challenge to treat in a tissue-sparing manner. The most commonly involved site for this rare disorder is the anogenital region. Surgery is considered as the gold standard therapy. In the last years, the topical use of imiquimod cream in the treatment of this condition has been reported.
MAIN OBSERVATIONS:

We present a case of a 59-year-old woman with primary extramammary Paget's disease of the vulva, in which a conservative approach to therapy was desired, and who underwent complete and stable remission with imiquimod cream. We also review the previous reports of patients with extramammary Paget's disease treated with imiquimod cream.
CONCLUSIONS:

Imiquimod therapy may be an alternative for primary as well as recurring extramammary Paget's disease. Treatment-associated morbidity is minimal compared with other therapies, such as surgery which may be debilitating.

Statistics

Citations

Altmetrics

Downloads

39 downloads since deposited on 26 Feb 2012
9 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:26 Feb 2012 18:30
Last Modified:07 Dec 2017 12:40
Publisher:Spejaliści Dermatolodzy, PL
ISSN:1898-7249
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.3315/jdcr.2011.1073
PubMed ID:22187578

Download

Download PDF  'Treatment of vulvar Paget disease with topical imiquimod: a case report and review of the literature'.
Preview
Content: Published Version
Filetype: PDF
Size: 1MB
View at publisher