A comprehensive hydrological modeling study in the drainage area of a hydropower reservoir in central Switzerland is presented. Two models were tested to reproduce the measured discharge dynamics: (1) a detailed energy-balance model (ALPINE3D) primarily designed for snow simulations; (2) a conceptual runoff model system (PREVAH), including a distributed temperature-index snow and ice melt model. Considerable effort was put into distributing available meteorological station data to the model grids as forcing data. The recent EU regional climate modeling initiative ENSEMBLES provided up-to-date climate predictions for two 30-a periods in mid and late 21st century. These were used to estimate evolutions in the water supply of the hydropower reservoir in response to expected climate changes. The simulations suggest a shift of spring peak-flow by almost two months for the end of the century. Warmer winter temperatures will cause higher winter base-flow. Due to glacier retreat, late-summer flow will decrease at the end of the century.