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Poorly differentiated oncocytic thyroid carcinoma - diagnostic implications and outcome


Dettmer, Matthias; Schmitt, Anja; Steinert, Hans; Moch, Holger; Komminoth, Paul; Perren, Aurel (2012). Poorly differentiated oncocytic thyroid carcinoma - diagnostic implications and outcome. Histopathology, 60(7):1045-1051.

Abstract

Dettmer M, Schmitt A, Steinert H, Moch H, Komminoth P & Perren A (2012) Histopathology Poorly differentiated oncocytic thyroid carcinoma - diagnostic implications and outcome Aims:  Poorly differentiated thyroid carcinomas (PDTC) are an ongoing diagnostic challenge. Although the Turin consensus criteria for PDTC excluded consideration of oncocytic tumours, the World Health Organization (WHO) classification does recognise an oncocytic variant of conventional PDTC. The aims of this study were to establish whether the Turin criteria can be applied to oncocytic PDTC, and to determine if there are prognostic differences between conventional and oncocytic PDTC. Methods and results:  We applied the Turin criteria to 129 thyroid carcinomas. We identified 18 oncocytic PDTC and 16 conventional PDTC. Kaplan-Meier analysis revealed a significantly worse outcome for oncocytic PDTC with regard to overall and tumour-specific survival but no difference for relapse-free survival, all of which were confirmed by multivariate analysis. There was no association of survival with gender, age or tumour stage. Conclusions:  The Turin criteria can be applied to oncocytic PDTC and patients with this variant have a decreased survival using conventional radioiodine treatment compared to conventional PDTC and might therefore be candidates for novel treatment modalities.

Abstract

Dettmer M, Schmitt A, Steinert H, Moch H, Komminoth P & Perren A (2012) Histopathology Poorly differentiated oncocytic thyroid carcinoma - diagnostic implications and outcome Aims:  Poorly differentiated thyroid carcinomas (PDTC) are an ongoing diagnostic challenge. Although the Turin consensus criteria for PDTC excluded consideration of oncocytic tumours, the World Health Organization (WHO) classification does recognise an oncocytic variant of conventional PDTC. The aims of this study were to establish whether the Turin criteria can be applied to oncocytic PDTC, and to determine if there are prognostic differences between conventional and oncocytic PDTC. Methods and results:  We applied the Turin criteria to 129 thyroid carcinomas. We identified 18 oncocytic PDTC and 16 conventional PDTC. Kaplan-Meier analysis revealed a significantly worse outcome for oncocytic PDTC with regard to overall and tumour-specific survival but no difference for relapse-free survival, all of which were confirmed by multivariate analysis. There was no association of survival with gender, age or tumour stage. Conclusions:  The Turin criteria can be applied to oncocytic PDTC and patients with this variant have a decreased survival using conventional radioiodine treatment compared to conventional PDTC and might therefore be candidates for novel treatment modalities.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:10 Apr 2012 09:13
Last Modified:05 Apr 2016 15:44
Publisher:Wiley-Blackwell
ISSN:0309-0167
Publisher DOI:https://doi.org/10.1111/j.1365-2559.2012.04188.x
PubMed ID:22348590

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