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X-Ray phase contrast imaging of soft tissue specimens


Kottler, C; Revol, V; Kaufmann, R; Maale, C; Stübinger, S; von Rechenberg, B; Kircher, P R; Urban, C (2011). X-Ray phase contrast imaging of soft tissue specimens. In: 2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, Valencia, Spain, 23 October 2011 - 29 October 2011, 4437-4440.

Abstract

In the presented work, we investigated the potential capabilities of contrast improvement in soft tissue achieved by x-ray phase contrast imaging. The Talbot-Lau interferometer method was implemented by means of x-ray diffraction gratings. Tomographic measurements were performed on prepared sam- ples containing specimens of different kinds of soft animal tissue. The results showed that phase contrast can provide additional and complementary visualization of soft tissue structures that are invisible to conventional, attenuation contrast x-ray imaging. As an example, the results obtained from the tomography of a bovine artery show that whereas the fat and connective tissue present around the artery can be seen with both absorption and phase contrast, the artery itself can only be recognized in the phase contrast image. Moreover, the situation is even more complicated for specimens containing not only soft tissue but also stronger absorbers such as bones or cartilage. Indeed, the strongly absorbing bones also lead to the scattering of the x- ray beam (due to their dense micro-structure), which results in a loss of the phase information. However, this issue relaxes when higher x-ray energies are used. Measurements of specimens (containing bones and soft tissue) were demonstrated with the set-up optimized for a mean x-ray energy of 50keV.

Abstract

In the presented work, we investigated the potential capabilities of contrast improvement in soft tissue achieved by x-ray phase contrast imaging. The Talbot-Lau interferometer method was implemented by means of x-ray diffraction gratings. Tomographic measurements were performed on prepared sam- ples containing specimens of different kinds of soft animal tissue. The results showed that phase contrast can provide additional and complementary visualization of soft tissue structures that are invisible to conventional, attenuation contrast x-ray imaging. As an example, the results obtained from the tomography of a bovine artery show that whereas the fat and connective tissue present around the artery can be seen with both absorption and phase contrast, the artery itself can only be recognized in the phase contrast image. Moreover, the situation is even more complicated for specimens containing not only soft tissue but also stronger absorbers such as bones or cartilage. Indeed, the strongly absorbing bones also lead to the scattering of the x- ray beam (due to their dense micro-structure), which results in a loss of the phase information. However, this issue relaxes when higher x-ray energies are used. Measurements of specimens (containing bones and soft tissue) were demonstrated with the set-up optimized for a mean x-ray energy of 50keV.

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Additional indexing

Item Type:Conference or Workshop Item (Speech), refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Center for Applied Biotechnology and Molecular Medicine
05 Vetsuisse Faculty > Veterinary Clinic > Equine Department
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Event End Date:29 October 2011
Deposited On:12 Mar 2012 11:22
Last Modified:13 Aug 2017 13:41
Series Name:IEEE Nuclear Science Symposium Conference Record
ISSN:1082-3654
ISBN:978-1-4673-0118-3
Publisher DOI:https://doi.org/10.1109/NSSMIC.2011.6153855
Official URL:http://www.nss-mic.org/2011/program/ListProgramDB.asp?session=MIC23

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