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Decision-making dysregulation in first-episode schizophrenia


Cattapan-Ludewig, K; Ludewig, S; Messerli, N; Vollenweider, F X; Seitz, A; Feldon, J; Paulus, M P (2008). Decision-making dysregulation in first-episode schizophrenia. Journal of Nervous and Mental Disease, 196(2):157-160.

Abstract

Studies with chronic schizophrenia patients have demonstrated that patients fluctuate between rigid and unpredictable responses in decision-making situations, a phenomenon which has been called dysregulation. The aim of this study was to investigate whether schizophrenia patients already display dysregulated behavior at the beginning of their illness. Thirty-two first-episode schizophrenia or schizophreniform patients and 30 healthy controls performed the two-choice prediction task. The decision-making behavior of first-episode patients was shown to be characterized by a high degree of dysregulation accompanied by low metric entropy and a tendency towards increased mutual information. These results indicate that behavioral abnormalities during the two-choice prediction task are already present during the early stages of the illness.

Abstract

Studies with chronic schizophrenia patients have demonstrated that patients fluctuate between rigid and unpredictable responses in decision-making situations, a phenomenon which has been called dysregulation. The aim of this study was to investigate whether schizophrenia patients already display dysregulated behavior at the beginning of their illness. Thirty-two first-episode schizophrenia or schizophreniform patients and 30 healthy controls performed the two-choice prediction task. The decision-making behavior of first-episode patients was shown to be characterized by a high degree of dysregulation accompanied by low metric entropy and a tendency towards increased mutual information. These results indicate that behavioral abnormalities during the two-choice prediction task are already present during the early stages of the illness.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:February 2008
Deposited On:11 Dec 2008 23:04
Last Modified:05 Apr 2016 12:36
Publisher:Lippincott Wiliams & Wilkins
ISSN:0022-3018
Publisher DOI:https://doi.org/10.1097/NMD.0b013e318162aa1b
PubMed ID:18277225

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