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Impact of recombinant platelet-derived growth factor BB on bone regeneration: a study in rabbits


Thoma, D S; Jung, R E; Hänseler, P; Hämmerle, C H F; Cochran, D L; Weber, F E (2012). Impact of recombinant platelet-derived growth factor BB on bone regeneration: a study in rabbits. International Journal of Periodontics and Restorative Dentistry, 32(2):195-202.

Abstract

The aim of this study was to test whether recombinant human platelet-derived growth factor BB (rhPDGF-BB) enhances bone regeneration in combination with Β-tricalcium phosphate (Β-TCP) granules or deproteinized bovine bone mineral (DBBM) compared to empty defects and Β-TCP granules alone. Four titanium cylinders were placed on the external cortical plates of seven rabbits' calvaria and randomly allocated to one of four groups: (1) empty, (2) Β-TCP, (3) Β-TCP + rhPDGF-BB, and (4) DBBM + rhPDGF-BB. The mean area of bone regeneration was 13.9% ± 8.4% (empty), 24.0% ± 14.8% (Β-TCP), 37.1% ± 8.9% (Β-TCP + rhPDGF-BB), and 64.4% ± 5.4% (DBBM + rhPDGF-BB), with the greatest bone regeneration noted for DBBM + rhPDGF-BB (P < .01). The fraction of bone substitute material varied between 48.3% ± 9.3% (DBBM + rhPDGF-BB), 53.1% ± 10.6% (Β-TCP + rhPDGF-BB), and 58.0% ± 14.8% (Β-TCP). rhPDGF-BB combined with DBBM showed the greatest potential to enhance bone regeneration.

Abstract

The aim of this study was to test whether recombinant human platelet-derived growth factor BB (rhPDGF-BB) enhances bone regeneration in combination with Β-tricalcium phosphate (Β-TCP) granules or deproteinized bovine bone mineral (DBBM) compared to empty defects and Β-TCP granules alone. Four titanium cylinders were placed on the external cortical plates of seven rabbits' calvaria and randomly allocated to one of four groups: (1) empty, (2) Β-TCP, (3) Β-TCP + rhPDGF-BB, and (4) DBBM + rhPDGF-BB. The mean area of bone regeneration was 13.9% ± 8.4% (empty), 24.0% ± 14.8% (Β-TCP), 37.1% ± 8.9% (Β-TCP + rhPDGF-BB), and 64.4% ± 5.4% (DBBM + rhPDGF-BB), with the greatest bone regeneration noted for DBBM + rhPDGF-BB (P < .01). The fraction of bone substitute material varied between 48.3% ± 9.3% (DBBM + rhPDGF-BB), 53.1% ± 10.6% (Β-TCP + rhPDGF-BB), and 58.0% ± 14.8% (Β-TCP). rhPDGF-BB combined with DBBM showed the greatest potential to enhance bone regeneration.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Clinic for Fixed and Removable Prosthodontics
04 Faculty of Medicine > Center for Dental Medicine > Clinic for Cranio-Maxillofacial Surgery
04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Research
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:April 2012
Deposited On:08 Jun 2012 08:37
Last Modified:05 Apr 2016 15:51
Publisher:Quintessence Publishing
ISSN:0198-7569
Related URLs:http://www.quintpub.com/journals/prd/gp.php?journal_name=PRD&name_abbr=IJPRD
PubMed ID:22292149

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