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Primitiver neuroektodermaler Tumor im Hoden: Molekulare Analyse und Diskussion der Entstehung


Brandt, S; Lohe, B; Vogetseder, A; Rüdiger, T; Moch, H; Bode, P (2012). Primitiver neuroektodermaler Tumor im Hoden: Molekulare Analyse und Diskussion der Entstehung. Der Pathologe:1-4.

Abstract

We describe a case of a testicular primitive neuroectodermal tumor (PNET) with intratubular germ cell neoplasia of the adjacent testicular parenchyma. The occurrence of testicular PNET is rare because malignant transformation of testicular germ cell tumors into somatic malignancy is uncommon. Based on morphological, immunohistochemical and molecular pathological findings these tumors resemble central PNETs as they otherwise typically occur in children without rearrangement of the Ewing sarcoma breakpoint region (EWSR) gene on chromosome 22. This case also showed no evidence for a translocation.

Abstract

We describe a case of a testicular primitive neuroectodermal tumor (PNET) with intratubular germ cell neoplasia of the adjacent testicular parenchyma. The occurrence of testicular PNET is rare because malignant transformation of testicular germ cell tumors into somatic malignancy is uncommon. Based on morphological, immunohistochemical and molecular pathological findings these tumors resemble central PNETs as they otherwise typically occur in children without rearrangement of the Ewing sarcoma breakpoint region (EWSR) gene on chromosome 22. This case also showed no evidence for a translocation.

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Additional indexing

Other titles:Primitive neuroectodermal tumor of the testis : Molecular analysis and discussion of genesis
Item Type:Journal Article, not refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
Dewey Decimal Classification:610 Medicine & health
Language:German
Date:2012
Deposited On:02 Jul 2012 15:30
Last Modified:05 Apr 2016 15:53
Publisher:Springer
ISSN:0172-8113
Publisher DOI:https://doi.org/10.1007/s00292-012-1608-6
PubMed ID:22706883

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