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MicroRNAs as components of regulatory networks controlling erythropoiesis


Azzouzi, Imane; Schmugge, Markus; Speer, Oliver (2012). MicroRNAs as components of regulatory networks controlling erythropoiesis. European Journal of Haematology, 89(1):1-9.

Abstract

Over the last two decades, the role of microRNAs has been extensively investigated, and it has become clear that these small non-coding RNAs play an essential role in several biological processes including erythropoiesis and that their dysregulation is associated with pathologies. Recent technical innovations have considerably advanced this field and allowed extensive study of microRNA expression and regulation in a variety of cell types. In erythropoiesis, microRNA regulation is involved at defined stages and promotes either stem cell proliferation or erythroid cell differentiation. In this review, while recapitulating the maturation steps of erythroid cells, we discuss the progresses in our understanding of microRNA regulation in the erythroid lineage and their contribution to erythroid disorders.

Abstract

Over the last two decades, the role of microRNAs has been extensively investigated, and it has become clear that these small non-coding RNAs play an essential role in several biological processes including erythropoiesis and that their dysregulation is associated with pathologies. Recent technical innovations have considerably advanced this field and allowed extensive study of microRNA expression and regulation in a variety of cell types. In erythropoiesis, microRNA regulation is involved at defined stages and promotes either stem cell proliferation or erythroid cell differentiation. In this review, while recapitulating the maturation steps of erythroid cells, we discuss the progresses in our understanding of microRNA regulation in the erythroid lineage and their contribution to erythroid disorders.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2012
Deposited On:17 Jul 2012 08:51
Last Modified:05 Apr 2016 15:53
Publisher:Wiley-Blackwell
ISSN:0902-4441
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1111/j.1600-0609.2012.01774.x
PubMed ID:22372390

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