Dyadic coping has received increased attention during the last decade, both in theory and empirical studies. Two main models of dyadic coping are proposed in the current literature: (1) a comparative approach in which each partner’s individual coping is compared with the other’s individual coping with regard to congruence or discrepancy and (2) a systemic model where dyadic coping is conceptualized as an interactive and reciprocal process. In this study, the predictive power of these two different models of dyadic coping is examined regarding relationship quality and well-being. The study is conducted with 443 Swiss couples. Results reveal that both dyadic coping measures are related to relationship quality and psychological well-being. However the systemic dyadic coping measure is a stronger predictor than the discrepancy measure for relationship quality. Both measures show weaker associations with well-being. Findings are discussed with regard to theoretical issues and their implication for practical work.