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Antiepileptic drugs and vitamin B6 plasma levels in adult patients


Linnebank, M; Moskau, S; Semmler, A; Widman, G; Weller, M; Kallweit, U; Elger, C E (2012). Antiepileptic drugs and vitamin B6 plasma levels in adult patients. Epilepsy Research, 101(1-2):182-184.

Abstract

Treatment with several antiepileptic drugs (AED) is associated with lower serum concentrations of folate or vitamin B12. This prospective monocenter study analyzed vitamin B6 blood levels in 400 serial patients with epilepsy, AED-treated (n=385), untreated (n=15) and healthy controls (n=233). The mean plasma vitamin B6 levels of the AED-treated (12.1±10.1; p=0.093) and the untreated patients (15.6±12.4; p=0.664) were not significantly different from the controls (13.9±15.2). These observations do not support the hypothesis that vitamin B6 blood levels are influenced by AED treatment.

Abstract

Treatment with several antiepileptic drugs (AED) is associated with lower serum concentrations of folate or vitamin B12. This prospective monocenter study analyzed vitamin B6 blood levels in 400 serial patients with epilepsy, AED-treated (n=385), untreated (n=15) and healthy controls (n=233). The mean plasma vitamin B6 levels of the AED-treated (12.1±10.1; p=0.093) and the untreated patients (15.6±12.4; p=0.664) were not significantly different from the controls (13.9±15.2). These observations do not support the hypothesis that vitamin B6 blood levels are influenced by AED treatment.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:08 Oct 2012 13:59
Last Modified:07 Dec 2017 15:03
Publisher:Elsevier
ISSN:0920-1211
Publisher DOI:https://doi.org/10.1016/j.eplepsyres.2012.03.002
PubMed ID:22464176

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