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Increased number of activated T cells in lymphocyte subsets of maltreated children: Data from a pilot study


Bielas, H; Jud, A; Lips, U; Reichenbach, J; Landolt, M A (2012). Increased number of activated T cells in lymphocyte subsets of maltreated children: Data from a pilot study. Journal of Psychosomatic Research, 73(4):313-318.

Abstract

OBJECTIVE: Maltreatment in childhood has been related to enduring changes in the immune system of adults, such as increased cell-mediated immune response.
PURPOSE: Due to the lack of data in children, this study examined lymphocyte subset numbers and distribution during youth.
METHODS: In 27 cases of 42 healthy but maltreated children, fully participating at follow-up 1-3years after the intervention of child protection team, and 19 cases of previously matched controls, analysis of blood samples by fluorescent activated cell sorter was consented.
RESULTS: With regard to age references, total lymphocyte counts were aberrant in maltreated children but not in controls. When compared to controls, the percentages and absolute numbers of activated (HLA-DR+) CD4+helper and CD8+cytotoxic T cells were significantly higher in maltreated children.
CONCLUSIONS: According to the typical distribution of HLA-DR+cells we assumed an increased stimulated cell-mediated immune function in maltreated children.

Abstract

OBJECTIVE: Maltreatment in childhood has been related to enduring changes in the immune system of adults, such as increased cell-mediated immune response.
PURPOSE: Due to the lack of data in children, this study examined lymphocyte subset numbers and distribution during youth.
METHODS: In 27 cases of 42 healthy but maltreated children, fully participating at follow-up 1-3years after the intervention of child protection team, and 19 cases of previously matched controls, analysis of blood samples by fluorescent activated cell sorter was consented.
RESULTS: With regard to age references, total lymphocyte counts were aberrant in maltreated children but not in controls. When compared to controls, the percentages and absolute numbers of activated (HLA-DR+) CD4+helper and CD8+cytotoxic T cells were significantly higher in maltreated children.
CONCLUSIONS: According to the typical distribution of HLA-DR+cells we assumed an increased stimulated cell-mediated immune function in maltreated children.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:02 Oct 2012 12:28
Last Modified:05 Apr 2016 15:58
Publisher:Elsevier
ISSN:0022-3999
Publisher DOI:https://doi.org/10.1016/j.jpsychores.2012.08.003
PubMed ID:22980539

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