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Körperliches Training bei mitochondrialen Erkrankungen


Petersen, J A; Toigo, M; Frese, S; Jung, H H (2012). Körperliches Training bei mitochondrialen Erkrankungen. Medizinische Genetik, 24(3):200-203.

Abstract

Exercise is a promising therapeutical option for the treatment of mitochondrial myopathies. Its efficacy and safety have been proven in various studies. In patients with mitochondrial myopathy, resistance training and aerobic exercise training lead to widely diversified effects: resistance training is thought to normalize the mitochondrial DNA (mtDNA) genotype in mature myofibers by enhancing the incorporation of satellite cells and thereby increasing the ratio of wild-type to mutant mtDNA (“gene shifting”). Aerobic exercise training induces mitochondrial biogenesis and helps breaking the vicious circle of low oxidative phosphorylation capacity, exercise intolerance, and progressive muscular deconditioning. Certain drugs act as inductors of mitochondrial biogenesis but their safety and efficacy in patients with mitochondrial myopathy have to be further investigated.

Abstract

Exercise is a promising therapeutical option for the treatment of mitochondrial myopathies. Its efficacy and safety have been proven in various studies. In patients with mitochondrial myopathy, resistance training and aerobic exercise training lead to widely diversified effects: resistance training is thought to normalize the mitochondrial DNA (mtDNA) genotype in mature myofibers by enhancing the incorporation of satellite cells and thereby increasing the ratio of wild-type to mutant mtDNA (“gene shifting”). Aerobic exercise training induces mitochondrial biogenesis and helps breaking the vicious circle of low oxidative phosphorylation capacity, exercise intolerance, and progressive muscular deconditioning. Certain drugs act as inductors of mitochondrial biogenesis but their safety and efficacy in patients with mitochondrial myopathy have to be further investigated.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
04 Faculty of Medicine > Center for Integrative Human Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:2012
Deposited On:02 Oct 2012 16:09
Last Modified:07 Dec 2017 15:12
Publisher:Springer
ISSN:0936-5931
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1007/s11825-012-0345-9

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