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Fibroblast cultures of patients with basal cell epithelioma exhibit a normal sensitivity to the genotoxic effect of ultraviolet irradiation


Rümmelein, Bettina; Eloo, Ulrike; Bielfeld, Volker; Ehlert, Ulrike; Weichenthal, Michael; Breitbart, Eckhard W; Rüdiger, Hugo W (1992). Fibroblast cultures of patients with basal cell epithelioma exhibit a normal sensitivity to the genotoxic effect of ultraviolet irradiation. Cancer Genetics and Cytogenetics, 61(1):74-76.

Abstract

Fibroblast cultures of 16 basal cell epithelioma (basalioma, BCE) patients with an unusu- ally young age at onset of disease (29-51 years; 42.5 +-7.04), and healthy normal controls (27-55 years; 40.73 +-9.52) were studied for chromosome instability induced by ultraviolet rays (UV). We used an UV source that emitted predominantly UV-A and UV-B at an intensity of 375 J/m2 and evaluated the induction of micronuclei (MN) and sister chromatid exchange (SCE). Young basalioma patients and normal controls showed no significant differences in MN and SCE frequencies, neither with respect to spontaneous nor to UV-induced values (MN spontaneous: 10.80 +- 5.65 vs.11.32 +- 8.21; UV-induced increase: 7.36 +- 4.40 vs. 9.93 +- 7.55; SCE spontaneous: 10.28 +- 1.61 vs. 10.72 +- 1.09; UV-induced increase: 7,30 +-2.19 vs. 7.55 +-2,14). We conclude from these data that an enhanced UV sensitivity as observed in cells from patients with cutaneous malignant melanoma and xeroderma pigmentosum is not a constitutive risk factor in basalioma patients.

Abstract

Fibroblast cultures of 16 basal cell epithelioma (basalioma, BCE) patients with an unusu- ally young age at onset of disease (29-51 years; 42.5 +-7.04), and healthy normal controls (27-55 years; 40.73 +-9.52) were studied for chromosome instability induced by ultraviolet rays (UV). We used an UV source that emitted predominantly UV-A and UV-B at an intensity of 375 J/m2 and evaluated the induction of micronuclei (MN) and sister chromatid exchange (SCE). Young basalioma patients and normal controls showed no significant differences in MN and SCE frequencies, neither with respect to spontaneous nor to UV-induced values (MN spontaneous: 10.80 +- 5.65 vs.11.32 +- 8.21; UV-induced increase: 7.36 +- 4.40 vs. 9.93 +- 7.55; SCE spontaneous: 10.28 +- 1.61 vs. 10.72 +- 1.09; UV-induced increase: 7,30 +-2.19 vs. 7.55 +-2,14). We conclude from these data that an enhanced UV sensitivity as observed in cells from patients with cutaneous malignant melanoma and xeroderma pigmentosum is not a constitutive risk factor in basalioma patients.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:06 Faculty of Arts > Institute of Psychology
Dewey Decimal Classification:150 Psychology
Language:English
Date:1992
Deposited On:12 Oct 2012 14:01
Last Modified:07 Dec 2017 15:20
Publisher:Elsevier
ISSN:0165-4608
Additional Information:Date: 7/1/
Publisher DOI:https://doi.org/10.1016/0165-4608(92)90374-H

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