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Cytotoxicity of ruthenium(II) piano-stool complexes with imidazole-based PN ligands


Huber, Wilhelm; Broehler, Philip; Waetjen, Wim; Frank, Walter; Spingler, Bernhard; Kunz, Peter C (2012). Cytotoxicity of ruthenium(II) piano-stool complexes with imidazole-based PN ligands. Journal of Organometallic Chemistry, 717:187-194.

Abstract

A series of p-cymene ruthenium(II) complexes with imidazol-2-yl phosphines as PN ligands was prepared. Depending on the number of imidazolyl substituents in the ligands Ph3-nP(im)(n) {1-3: n = 1-3, im imidazol-2-yl (a), 1-methylimidazol-2-yl (b)} different coordination modes were observed: kappa P, kappa N-2,N or kappa N-3,N,N. The complexes were tested for their cytotoxicity in different cancer cell lines. Most of the compounds were found to be non-toxic; The compounds (p-cymene)Ru(1a)Cl-2] (4a) shows cytotoxicity towards A2780sens and Hct116 cells in the mM range but not in H4IIE cells. The cytotoxicity is decreased upon introduction of a methyl group as (p-cymene)Ru(1b)Cl-2] (4b) shows only modest toxicities in the cell lines investigated. The kappa P compound (p-cymene)Ru(2a)Cl-2] (5a) shows selective toxicity in H4IIE cells after 72 h whereas the kappa N-2, N compound (p-cymene)Ru(2a) Cl] OTf (5a') showed no toxicity in the cell lines investigated which again. (C) 2012 Elsevier B. V. All rights reserved.

Abstract

A series of p-cymene ruthenium(II) complexes with imidazol-2-yl phosphines as PN ligands was prepared. Depending on the number of imidazolyl substituents in the ligands Ph3-nP(im)(n) {1-3: n = 1-3, im imidazol-2-yl (a), 1-methylimidazol-2-yl (b)} different coordination modes were observed: kappa P, kappa N-2,N or kappa N-3,N,N. The complexes were tested for their cytotoxicity in different cancer cell lines. Most of the compounds were found to be non-toxic; The compounds (p-cymene)Ru(1a)Cl-2] (4a) shows cytotoxicity towards A2780sens and Hct116 cells in the mM range but not in H4IIE cells. The cytotoxicity is decreased upon introduction of a methyl group as (p-cymene)Ru(1b)Cl-2] (4b) shows only modest toxicities in the cell lines investigated. The kappa P compound (p-cymene)Ru(2a)Cl-2] (5a) shows selective toxicity in H4IIE cells after 72 h whereas the kappa N-2, N compound (p-cymene)Ru(2a) Cl] OTf (5a') showed no toxicity in the cell lines investigated which again. (C) 2012 Elsevier B. V. All rights reserved.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:October 2012
Deposited On:19 Oct 2012 10:59
Last Modified:16 Feb 2018 23:56
Publisher:Elsevier
ISSN:0022-328X
OA Status:Green
Publisher DOI:https://doi.org/10.1016/j.jorganchem.2012.06.027
Other Identification Number:ISI:000308722600024

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