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A Comparative Study of Tricarbonylmanganese Photoactivatable CO Releasing Molecules (PhotoCORMs) by Using the Myoglobin Assay and Time-Resolved IR Spectroscopy


Huber, Wilhelm; Linder, Rolf; Niesel, Johanna; Schatzschneider, Ulrich; Spingler, Bernhard; Kunz, Peter C (2012). A Comparative Study of Tricarbonylmanganese Photoactivatable CO Releasing Molecules (PhotoCORMs) by Using the Myoglobin Assay and Time-Resolved IR Spectroscopy. European Journal of Inorganic Chemistry, 2012(19):3140-3146.

Abstract

Tricarbonylmanganese(I) complexes of the ligands tris(imidazol-4-yl)phosphane (4-tipH), tris(1,4-diisopropylimidazol-2-yl)phosphane (2-tipiPr2), tris(pyridin-2-yl)phosphane (tpp) and tris(N-methylimidazol-2-yl)carbinol (2-ticNMe) were prepared. These act as N,N,N tripodal chelators. The solid-state structure of Mn(CO)3(tpp)]OTf was determined by X-ray diffraction. The potential of these complexes to act as photoactivatable CO-releasing molecules (PhotoCORMs) was studied with the UV/Vis spectroscopy-based myoglobin assay as well as by time-resolved IR spectroscopy. Within the series of compounds prepared, the steric bulk of the imidazolyl groups seems to significantly influence the CO-release kinetics and stoichiometry when using the myoglobin assay. In contrast, the time-resolved IR data suggest release of all carbonyl ligands upon irradiation. This effect points to a much closer association of myoglobin and PhotoCORMs than previously thought and will require further investigation.

Abstract

Tricarbonylmanganese(I) complexes of the ligands tris(imidazol-4-yl)phosphane (4-tipH), tris(1,4-diisopropylimidazol-2-yl)phosphane (2-tipiPr2), tris(pyridin-2-yl)phosphane (tpp) and tris(N-methylimidazol-2-yl)carbinol (2-ticNMe) were prepared. These act as N,N,N tripodal chelators. The solid-state structure of Mn(CO)3(tpp)]OTf was determined by X-ray diffraction. The potential of these complexes to act as photoactivatable CO-releasing molecules (PhotoCORMs) was studied with the UV/Vis spectroscopy-based myoglobin assay as well as by time-resolved IR spectroscopy. Within the series of compounds prepared, the steric bulk of the imidazolyl groups seems to significantly influence the CO-release kinetics and stoichiometry when using the myoglobin assay. In contrast, the time-resolved IR data suggest release of all carbonyl ligands upon irradiation. This effect points to a much closer association of myoglobin and PhotoCORMs than previously thought and will require further investigation.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:July 2012
Deposited On:17 Oct 2012 13:11
Last Modified:05 Apr 2016 15:59
Publisher:Wiley-Blackwell
ISSN:1434-1948
Publisher DOI:https://doi.org/10.1002/ejic.201200115
Other Identification Number:ISI:000305506800005

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