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Synthesis of Cyclopentapyridine and Thienopyridine derivatives as potential calcium channel modulators


Gündüz, M; Şafak, C; Kaygısız, B; Koşar, B; Şimşek, R; Erol, K; Linden, Anthony (2012). Synthesis of Cyclopentapyridine and Thienopyridine derivatives as potential calcium channel modulators. Arzneimittelforschung, 62(4):167-175.

Abstract

In this study, novel condensed 1,4-dihydropyridines bearing cyclopentanone (1-21) or tetrahydrothiophene-1,1-dioxide ring (22-42) with various ester substituents were synthesized via a modified Hantzsch reaction and their calcium channel modulator activities were investigated on isolated rat ileum and rat thoracic aorta. The introduction of a cyclopentanone ring fused to the 1,4-dihydropyridine nucleus and methyl, ethyl and allyl moieties to the ester group led to more active calcium modulators.

Abstract

In this study, novel condensed 1,4-dihydropyridines bearing cyclopentanone (1-21) or tetrahydrothiophene-1,1-dioxide ring (22-42) with various ester substituents were synthesized via a modified Hantzsch reaction and their calcium channel modulator activities were investigated on isolated rat ileum and rat thoracic aorta. The introduction of a cyclopentanone ring fused to the 1,4-dihydropyridine nucleus and methyl, ethyl and allyl moieties to the ester group led to more active calcium modulators.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Uncontrolled Keywords:1,4-Dihydropyridine thienopyridine cyclopentapyridine alcium channel modulator
Language:English
Date:2012
Deposited On:19 Oct 2012 11:44
Last Modified:05 Apr 2016 16:00
Publisher:Georg Thieme
ISSN:0004-4172
Funders:Hacettepe University, Scientifi c Research and Development Offi ce (Project No: 1713), The Scientifi c and Technological Research Council of Turkey-National Scholarship Programme for PhD Students
Additional Information:Copyright: Georg Thieme Verlag
Publisher DOI:https://doi.org/10.1055/s-0031-1299744
PubMed ID:22286976

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