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Mutations modulating Raf signaling in Drosophila eye development.


Dickson, B J; van der Straten, A; Dominguez, M; Hafen, E (1996). Mutations modulating Raf signaling in Drosophila eye development. Genetics, 142(1):163-171.

Abstract

The R7 fate is specified during Drosophila eye development by an inductive signal transduced intracellularly via the Raf kinase. We have performed a genetic screen for dominant mutations that alter the efficiency with which cells respond to a constitutively activated Raf kinase. Such mutations may affect genes involved in signal transduction downstream of Raf. We have isolated 44 mutations that define eight genes. One of these encodes a mitogen-activated protein kinase homologue: another is a putative target gene of this signaling pathway. We present the results of this screen in detail, as well as a preliminary genetic analysis of the six loci still to be characterized molecularly.

Abstract

The R7 fate is specified during Drosophila eye development by an inductive signal transduced intracellularly via the Raf kinase. We have performed a genetic screen for dominant mutations that alter the efficiency with which cells respond to a constitutively activated Raf kinase. Such mutations may affect genes involved in signal transduction downstream of Raf. We have isolated 44 mutations that define eight genes. One of these encodes a mitogen-activated protein kinase homologue: another is a putative target gene of this signaling pathway. We present the results of this screen in detail, as well as a preliminary genetic analysis of the six loci still to be characterized molecularly.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Zoology (former)
Dewey Decimal Classification:570 Life sciences; biology
590 Animals (Zoology)
Language:English
Date:1 January 1996
Deposited On:11 Feb 2008 12:17
Last Modified:06 Dec 2017 12:55
Publisher:Genetics Society of America
ISSN:0016-6731
Free access at:PubMed ID. An embargo period may apply.
Related URLs:http://www.genetics.org/cgi/content/abstract/142/1/163
PubMed ID:8770593

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