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Towards polymer diagnostic agents - Copolymers of N-(2-hydroxypropyl)-methacrylamide and bis(2-pyridylmethyl)-4-vinylbenzylamine: Synthesis, characterisation and Re(CO)(3)-labelling


Kunz, Peter C; Brueckmann, Nadine E; Spingler, Bernhard (2007). Towards polymer diagnostic agents - Copolymers of N-(2-hydroxypropyl)-methacrylamide and bis(2-pyridylmethyl)-4-vinylbenzylamine: Synthesis, characterisation and Re(CO)(3)-labelling. European Journal of Inorganic Chemistry, (3):394-399.

Abstract

Diagnosis of early stage angiogenic tumours is fundamental for cancer therapy. In this study we present the synthesis and characterisation of functionalised HPMA-copolymers with optimal molecular weights that meet the demands of the enhanced permeability and retention (EPR) effect. Rhenium tricarbonyl complexes of the tripodal ligands bis(2-pyridylmethyl)benzylamine (1a) and bis (2-pyridylmethyl) -4-vinylbenzylamine (1b) were prepared and characterised by H-1 NMR and IR spectroscopy, mass spectrometry and X-ray diffraction. Ligand 1b was copolymerised with N-(2-hydroxypropyl)methacrylamide (HPMA), and the resulting copolymer was treated with (nBu(4)N)(2)Re(CO)(3)Br-3] to yield a Re(CO)(3)-labelled copolymer. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim., Germany, 2007).

Abstract

Diagnosis of early stage angiogenic tumours is fundamental for cancer therapy. In this study we present the synthesis and characterisation of functionalised HPMA-copolymers with optimal molecular weights that meet the demands of the enhanced permeability and retention (EPR) effect. Rhenium tricarbonyl complexes of the tripodal ligands bis(2-pyridylmethyl)benzylamine (1a) and bis (2-pyridylmethyl) -4-vinylbenzylamine (1b) were prepared and characterised by H-1 NMR and IR spectroscopy, mass spectrometry and X-ray diffraction. Ligand 1b was copolymerised with N-(2-hydroxypropyl)methacrylamide (HPMA), and the resulting copolymer was treated with (nBu(4)N)(2)Re(CO)(3)Br-3] to yield a Re(CO)(3)-labelled copolymer. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim., Germany, 2007).

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:January 2007
Deposited On:23 Oct 2012 12:50
Last Modified:05 Apr 2016 16:01
Publisher:Wiley-Blackwell
ISSN:1434-1948
Publisher DOI:https://doi.org/10.1002/ejic.200600824
Other Identification Number:ISI:000244219900005

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