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Use of abatacept in rheumatoid arthritis


von Kempis, Johannes; Dudler, Jean; Hasler, Paul; Kyburz, Diego; Tyndall, Alan; Zufferey, Pascal; Villiger, Peter M (2012). Use of abatacept in rheumatoid arthritis. Swiss Medical Weekly, 142:w13581.

Abstract

Abatacept (CTLA-Ig), a modulator of T-lymphocyte activation, has been approved by the Swiss health regulatory agency Swissmedic for the treatment of active rheumatoid arthritis (RA). This article summarises the key trial findings for this biologic agent in RA in different situations such as early erosive rheumatoid arthritis (RA), biologic-naïve RA, RA before and after the use of methotrexate or TNF-inhibitors and includes safety information from these trials. Based on these data, recommendations for clinical practice in Switzerland are made by a panel of experts.

Abstract

Abatacept (CTLA-Ig), a modulator of T-lymphocyte activation, has been approved by the Swiss health regulatory agency Swissmedic for the treatment of active rheumatoid arthritis (RA). This article summarises the key trial findings for this biologic agent in RA in different situations such as early erosive rheumatoid arthritis (RA), biologic-naïve RA, RA before and after the use of methotrexate or TNF-inhibitors and includes safety information from these trials. Based on these data, recommendations for clinical practice in Switzerland are made by a panel of experts.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:16 Nov 2012 14:28
Last Modified:05 Apr 2016 16:05
Publisher:EMH Swiss Medical Publishers
ISSN:0036-7672
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.4414/smw.2012.13581
PubMed ID:22581564

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