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Primary cutaneous CD8+ small- to medium-sized Lymphoproliferative disorder in extrafacial sites: Clinicopathologic features and concept on their classification


Kempf, Werner; Kazakov, Dmitry V; Cozzio, Antonio; Kamarashev, Jivko; Kerl, Katrin; Plaza, Tobias; Metze, Dieter (2013). Primary cutaneous CD8+ small- to medium-sized Lymphoproliferative disorder in extrafacial sites: Clinicopathologic features and concept on their classification. American Journal of Dermatopathology, 35(2):159-166.

Abstract

ABSTRACT: Three cases with CD8+ small- to medium-sized lymphoproliferations in the skin at extrafacial sites are described. Clinically, the patients presented with papulonodular or plaque-like lesions without preceding patches. Histopathologically, nonepidermotropic nodular or diffuse infiltrates were composed of small- to medium-sized pleomorphic lymphocytes, which expressed CD8 (more than 80% of the cells) and granzyme B (60%-70% of the cells), but were negative for CD4, CD30, and CD56. There was no association with Epstein-Barr virus. A clonal T-cell population was detected in 2 patients. Staging examinations did not reveal extracutaneous involvement. The 2 patients with solitary lesions underwent complete remission after radiation therapy, whereas 1 patient developed multifocal lesions and several recurrences. These CD8+ small- to medium-sized lymphoproliferations of the skin at extrafacial sites may belong to a spectrum of phenotypically and prognostically heterogeneous cutaneous small- to medium-sized lymphoid proliferations, which are characterized by an indolent course in most patients.

Abstract

ABSTRACT: Three cases with CD8+ small- to medium-sized lymphoproliferations in the skin at extrafacial sites are described. Clinically, the patients presented with papulonodular or plaque-like lesions without preceding patches. Histopathologically, nonepidermotropic nodular or diffuse infiltrates were composed of small- to medium-sized pleomorphic lymphocytes, which expressed CD8 (more than 80% of the cells) and granzyme B (60%-70% of the cells), but were negative for CD4, CD30, and CD56. There was no association with Epstein-Barr virus. A clonal T-cell population was detected in 2 patients. Staging examinations did not reveal extracutaneous involvement. The 2 patients with solitary lesions underwent complete remission after radiation therapy, whereas 1 patient developed multifocal lesions and several recurrences. These CD8+ small- to medium-sized lymphoproliferations of the skin at extrafacial sites may belong to a spectrum of phenotypically and prognostically heterogeneous cutaneous small- to medium-sized lymphoid proliferations, which are characterized by an indolent course in most patients.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2013
Deposited On:14 Dec 2012 09:56
Last Modified:07 Dec 2017 16:59
Publisher:Lippincott, Williams & Wilkins
ISSN:0193-1091
Additional Information:This is a non-final version of an article published in final form in Kempf, Werner; Kazakov, Dmitry V; Cozzio, Antonio; Kamarashev, Jivko; Kerl, Katrin; Plaza, Tobias; Metze, Dieter (2012). Primary cutaneous CD8+ small- to medium-sized Lymphoproliferative disorder in extrafacial sites: Clinicopathologic features and concept on their classification. American Journal of Dermatopathology:Epub ahead of print.
Publisher DOI:https://doi.org/10.1097/DAD.0b013e31825c3a33
PubMed ID:22885550

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