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Comparison of ovine herpesvirus 2 genomes isolated from domestic sheep (Ovis aries) and a clinically affected cow (Bos bovis)


Taus, N S; Herndon, D R; Traul, D L; Stewart, J P; Ackermann, M; Li, H; Knowles, D P; Lewis, G S; Brayton, K A (2007). Comparison of ovine herpesvirus 2 genomes isolated from domestic sheep (Ovis aries) and a clinically affected cow (Bos bovis). Journal of General Virology, 88:40-45.

Abstract

The rhadinovirus Ovine herpesvirus 2 (OvHV-2) is the causative agent of sheep-associated malignant catarrhal fever. OvHV-2 primarily affects ruminants and has a worldwide distribution. In this study, a composite sequence of OvHV-2 genomic DNA isolated from nasal secretions of sheep experiencing virus-shedding episodes was determined and compared with the sequence of OvHV-2 DNA isolated from a lymphoblastoid cell line derived from a clinically affected cow. The study confirmed the OvHV-2 sequence information determined for the cell line-isolated DNA and showed no apparently significant changes in the OvHV-2 genome during passage through a clinically susceptible species with subsequent maintenance in vitro. Amino acid identity between
the predicted open reading frames (ORFs) of the two genomes was 94–100 %, except for ORF73, which had an identity of 83 %. Polymorphism in ORF73 was due primarily to variability in
the G/E-rich repetitive central region of the ORF.

Abstract

The rhadinovirus Ovine herpesvirus 2 (OvHV-2) is the causative agent of sheep-associated malignant catarrhal fever. OvHV-2 primarily affects ruminants and has a worldwide distribution. In this study, a composite sequence of OvHV-2 genomic DNA isolated from nasal secretions of sheep experiencing virus-shedding episodes was determined and compared with the sequence of OvHV-2 DNA isolated from a lymphoblastoid cell line derived from a clinically affected cow. The study confirmed the OvHV-2 sequence information determined for the cell line-isolated DNA and showed no apparently significant changes in the OvHV-2 genome during passage through a clinically susceptible species with subsequent maintenance in vitro. Amino acid identity between
the predicted open reading frames (ORFs) of the two genomes was 94–100 %, except for ORF73, which had an identity of 83 %. Polymorphism in ORF73 was due primarily to variability in
the G/E-rich repetitive central region of the ORF.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Virology
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:2007
Deposited On:25 Mar 2009 10:40
Last Modified:05 Apr 2016 12:38
Publisher:Society for General Microbiology
ISSN:0022-1317
Publisher DOI:https://doi.org/10.1099/vir.0.82285-0
PubMed ID:17170434

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