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The need for improved neutropenia risk assessment in DLBCL patients receiving R-CHOP-21: findings from clinical practice


Salar, Antonio; Haioun, Corinne; Rossi, Francesca G; Duehrsen, Ulrich; Pettengell, Ruth; Johnsen, Hans E; Jaeger, Ulrich; Verhoef, Gregor; Schwenkglenks, Matthias; Bacon, Pamela; Bendall, Kate; Lugtenburg, Pieternella J (2012). The need for improved neutropenia risk assessment in DLBCL patients receiving R-CHOP-21: findings from clinical practice. Leukemia Research, 36(5):548-553.

Abstract

Febrile neutropenia (FN) risk-assessment and granulocyte-colony stimulating factor (G-CSF) prophylaxis use in clinical practice was evaluated in patients with diffuse large B-cell lymphoma receiving R-CHOP-21. More G-CSF primary prophylaxis was used in patients assessed as high FN risk, but R-CHOP-21 was associated with substantial myelotoxicity in both high- and low-risk groups. In a multivariate analysis, older age, poor performance status, lower baseline hemoglobin, and lack of G-CSF prophylaxis were significantly associated with occurrence of FN in any cycle. Results highlight the need for improved FN risk-assessment and thorough guideline adherence to further reduce FN and better support chemotherapy delivery.

Abstract

Febrile neutropenia (FN) risk-assessment and granulocyte-colony stimulating factor (G-CSF) prophylaxis use in clinical practice was evaluated in patients with diffuse large B-cell lymphoma receiving R-CHOP-21. More G-CSF primary prophylaxis was used in patients assessed as high FN risk, but R-CHOP-21 was associated with substantial myelotoxicity in both high- and low-risk groups. In a multivariate analysis, older age, poor performance status, lower baseline hemoglobin, and lack of G-CSF prophylaxis were significantly associated with occurrence of FN in any cycle. Results highlight the need for improved FN risk-assessment and thorough guideline adherence to further reduce FN and better support chemotherapy delivery.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:20 Dec 2012 16:23
Last Modified:05 Apr 2016 16:12
Publisher:Elsevier
ISSN:0145-2126
Publisher DOI:https://doi.org/10.1016/j.leukres.2012.02.002
PubMed ID:22385870

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