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β-Hairpin protein epitope mimetic technology in drug discovery


Obrecht, Daniel; Chevalier, Eric; Moehle, Kerstin; Robinson, John A (2012). β-Hairpin protein epitope mimetic technology in drug discovery. Drug Discovery Today: Technologies, 9(1):e63-e69.

Abstract

Epitopes involved in protein–protein and protein–nucleic acid interactions provide ideal starting points for rational structure-based inhibitor design. The process of design and optimization of epitope mimetics is now emerging as an innovative new approach in drug discovery. Although often derided as unsuitable for drug development, we provide examples to show how peptidomimetics can provide a new generation of drug candidates to tackle some of the most challenging targets in pharmaceutical research, and address some of the most pressing current threats to human health.

Abstract

Epitopes involved in protein–protein and protein–nucleic acid interactions provide ideal starting points for rational structure-based inhibitor design. The process of design and optimization of epitope mimetics is now emerging as an innovative new approach in drug discovery. Although often derided as unsuitable for drug development, we provide examples to show how peptidomimetics can provide a new generation of drug candidates to tackle some of the most challenging targets in pharmaceutical research, and address some of the most pressing current threats to human health.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:March 2012
Deposited On:11 Jan 2013 08:18
Last Modified:10 Aug 2017 20:35
Publisher:Elsevier
ISSN:1740-6749
Publisher DOI:https://doi.org/10.1016/j.ddtec.2011.07.006

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