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Redox rescues virus from ER trap


Burckhardt, C J; Greber, U F (2008). Redox rescues virus from ER trap. Nature Cell Biology, 10(1):9-11.

Abstract

How viruses manage to resist physical and chemical stress and yet open their protective coats during cell infection has been a longstanding, fundamental question. A study with the DNA tumour virus SV40 now shows that protein folding and quality-control factors of the endoplasmic reticulum reshuffle disulfide bonds within the viral capsid, providing a molecular mechanism for the exit of infectious virions from the endoplasmic reticulum.

Abstract

How viruses manage to resist physical and chemical stress and yet open their protective coats during cell infection has been a longstanding, fundamental question. A study with the DNA tumour virus SV40 now shows that protein folding and quality-control factors of the endoplasmic reticulum reshuffle disulfide bonds within the viral capsid, providing a molecular mechanism for the exit of infectious virions from the endoplasmic reticulum.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:January 2008
Deposited On:11 Feb 2008 12:17
Last Modified:06 Dec 2017 12:56
Publisher:Nature Publishing Group
ISSN:1465-7392
Publisher DOI:https://doi.org/10.1038/ncb0108-9
PubMed ID:18172426

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