Header

UZH-Logo

Maintenance Infos

Acquitting an APC: DCs found "not guilty" after trial by ablation


Becher, Burkhard; Greter, Melanie (2012). Acquitting an APC: DCs found "not guilty" after trial by ablation. European Journal of Immunology, 42(10):2551-2554.

Abstract

There is a large body of evidence demonstrating that DCs are the most efficient and specialized APCs for T-cell priming, both in the context of host defense against pathogens and during the development of T-cell-mediated autoimmune responses; however, this concept is currently being challenged by a series of conflicting observations using genetically engineered mice in which DCs are either constitutively or inducibly ablated. In this issue of the European Journal of Immunology, Isaksson et al. [Eur. J. Immunol. 2012, 42: 2555-2563] report the use of mice in which CD11c(hi) cells can be ablated by injecting diphtheria toxin in vivo. The authors then induced EAE and found that, surprisingly, the mice were fully susceptible to the disease; thus, challenging the dogma that DCs are a mandatory APC population for the priming of autoimmune T(H) cells or T-cell-mediated immune responses. Here, we will analyze the authors' findings in the context of observations made by others and critically discuss whether DCs can really be dismissed as crucial APCs.

Abstract

There is a large body of evidence demonstrating that DCs are the most efficient and specialized APCs for T-cell priming, both in the context of host defense against pathogens and during the development of T-cell-mediated autoimmune responses; however, this concept is currently being challenged by a series of conflicting observations using genetically engineered mice in which DCs are either constitutively or inducibly ablated. In this issue of the European Journal of Immunology, Isaksson et al. [Eur. J. Immunol. 2012, 42: 2555-2563] report the use of mice in which CD11c(hi) cells can be ablated by injecting diphtheria toxin in vivo. The authors then induced EAE and found that, surprisingly, the mice were fully susceptible to the disease; thus, challenging the dogma that DCs are a mandatory APC population for the priming of autoimmune T(H) cells or T-cell-mediated immune responses. Here, we will analyze the authors' findings in the context of observations made by others and critically discuss whether DCs can really be dismissed as crucial APCs.

Statistics

Citations

3 citations in Web of Science®
3 citations in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2012
Deposited On:17 Jan 2013 13:26
Last Modified:05 Apr 2016 16:17
Publisher:Wiley-VCH Verlag Berlin
ISSN:0014-2980
Publisher DOI:https://doi.org/10.1002/eji.201242928
PubMed ID:23042652

Download

Full text not available from this repository.
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations