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New coil positioning method for interleaved transcranial magnetic stimulation (TMS)/functional MRI (fMRI) and its validation in a motor cortex study


Moisa, Marius; Pohmann, Rolf; Ewald, Lars; Thielscher, Axel (2009). New coil positioning method for interleaved transcranial magnetic stimulation (TMS)/functional MRI (fMRI) and its validation in a motor cortex study. Journal of Magnetic Resonance Imaging (JMRI), 29(1):189-197.

Abstract

Purpose To develop and test a novel method for coil placement in interleaved transcranial magnetic stimulation (TMS)/functional MRI (fMRI) studies.Materials and Methods Initially, a desired TMS coil position at the subject's head is recorded using a neuronavigation system. Subsequently, a custom-made holding device is used for coil placement inside the MR scanner. The parameters of the device corresponding to the prerecorded position are automatically determined from a fast structural image acquired directly before the experiment. The spatial accuracy of our method was verified on a phantom. Finally, in a study on five subjects, the coil was placed above the cortical representation of a hand muscle in M1 and the blood oxygenation level-dependent (BOLD) responses to short repetitive TMS (rTMS) trains were assessed using echo-planar imaging (EPI) recordings.Results The spatial accuracy of our method is in the range of 2.9 ± 1.3 (SD) mm. Motor cortex stimulation resulted in robust BOLD activations in motor- and auditoryrelated brain areas, with the activation in M1 being localized in the hand knob.Conclusion We present a user-friendly method for TMS coil positioning in the MR scanner that exhibits good spatial accuracy and speeds up the setup of the experiment. The motor-cortex study proves the viability of the approach and validates our interleaved TMS/fMRI setup.

Abstract

Purpose To develop and test a novel method for coil placement in interleaved transcranial magnetic stimulation (TMS)/functional MRI (fMRI) studies.Materials and Methods Initially, a desired TMS coil position at the subject's head is recorded using a neuronavigation system. Subsequently, a custom-made holding device is used for coil placement inside the MR scanner. The parameters of the device corresponding to the prerecorded position are automatically determined from a fast structural image acquired directly before the experiment. The spatial accuracy of our method was verified on a phantom. Finally, in a study on five subjects, the coil was placed above the cortical representation of a hand muscle in M1 and the blood oxygenation level-dependent (BOLD) responses to short repetitive TMS (rTMS) trains were assessed using echo-planar imaging (EPI) recordings.Results The spatial accuracy of our method is in the range of 2.9 ± 1.3 (SD) mm. Motor cortex stimulation resulted in robust BOLD activations in motor- and auditoryrelated brain areas, with the activation in M1 being localized in the hand knob.Conclusion We present a user-friendly method for TMS coil positioning in the MR scanner that exhibits good spatial accuracy and speeds up the setup of the experiment. The motor-cortex study proves the viability of the approach and validates our interleaved TMS/fMRI setup.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:03 Faculty of Economics > Department of Economics
Dewey Decimal Classification:330 Economics
Language:English
Date:2009
Deposited On:28 Feb 2013 09:50
Last Modified:07 Dec 2017 18:12
Publisher:Wiley-Blackwell
ISSN:1053-1807
Free access at:Official URL. An embargo period may apply.
Publisher DOI:https://doi.org/10.1002/jmri.21611
PubMed ID:19097080
Other Identification Number:merlin-id:4690

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