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The accuracy of the single intradermal comparative skin test for the diagnosis of bovine tuberculosis - estimated from a systematic literature search


Hartnack, S; Torgerson, P R (2012). The accuracy of the single intradermal comparative skin test for the diagnosis of bovine tuberculosis - estimated from a systematic literature search. Mycobacterial Diseases , 2(6):1000120.

Abstract

Background: Bovine Tuberculosis (bTN) elimination programs are based on test-and-slaughter strategies. No diagnostic test used in the control of Bovine Tuberculosis (bTB), a zoonotic disease, is a perfect gold standard having a diagnostic sensitivity and specificity of 100%. Methods: To find relevant data to assess diagnostic accuracy of one variant of the tuberculin test, the Single Intradermal Comparative Cervical Tuberculin Test (SICCT) used in the diagnosis of bTB a systematic literature search was performed. To estimate diagnostic test accuracies of the SICCT, a Bayesian latent class analysis has been undertaken. Results: Only one eligible study was found. Assuming bacterial isolation has a specificity of 100%, specificity of gross lesion detection and histopathology were estimated as 90% and 97% respectively. Estimates of the sensitivity of the Single Intradermal Comparative Cervical Tuberculin Test (SICCT), gross lesion detection, histopathology and bacteriological isolation were 80%, 89%, 93% and 98% respectively. The design of this study precluded estimating the SICCT specificity, although official UK surveillance data indicates specificity greater than 99.67%. Conclusion: Studies to estimate the diagnostic performance of key tests for bTB are lacking, yet essential for an informed debate in regard to bTB public health policy.

Abstract

Background: Bovine Tuberculosis (bTN) elimination programs are based on test-and-slaughter strategies. No diagnostic test used in the control of Bovine Tuberculosis (bTB), a zoonotic disease, is a perfect gold standard having a diagnostic sensitivity and specificity of 100%. Methods: To find relevant data to assess diagnostic accuracy of one variant of the tuberculin test, the Single Intradermal Comparative Cervical Tuberculin Test (SICCT) used in the diagnosis of bTB a systematic literature search was performed. To estimate diagnostic test accuracies of the SICCT, a Bayesian latent class analysis has been undertaken. Results: Only one eligible study was found. Assuming bacterial isolation has a specificity of 100%, specificity of gross lesion detection and histopathology were estimated as 90% and 97% respectively. Estimates of the sensitivity of the Single Intradermal Comparative Cervical Tuberculin Test (SICCT), gross lesion detection, histopathology and bacteriological isolation were 80%, 89%, 93% and 98% respectively. The design of this study precluded estimating the SICCT specificity, although official UK surveillance data indicates specificity greater than 99.67%. Conclusion: Studies to estimate the diagnostic performance of key tests for bTB are lacking, yet essential for an informed debate in regard to bTB public health policy.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Chair in Veterinary Epidemiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2012
Deposited On:22 Jan 2013 12:34
Last Modified:30 May 2017 13:50
Publisher:OMICS
Publisher DOI:https://doi.org/10.4172/2161-1068.1000120
Official URL:http://www.omicsonline.org/2161-1068/2161-1068-2-120.php?aid=8272

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