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Evidence for the accumulation of Abeta immunoreactive material in the human brain and in transgenic animal models


Cuello, A Claudio; Allard, Simon; Ferretti, Maria Teresa (2012). Evidence for the accumulation of Abeta immunoreactive material in the human brain and in transgenic animal models. Life Sciences, 91(23-24):1141-1147.

Abstract

In this review we highlight the evidence for an intracellular origin of Abeta (Aβ) amyloid peptides as well as the observations for a pathological accumulation of these peptides in Alzheimer's disease and Down syndrome, as well as in transgenic animal models. We deliberate on the controversy as to whether the intracellular Aβ immunoreactive material is simply an accumulation of unprocessed full length amyloid precursor protein (APP) or a mix of processed APP fragments including Aβ. Finally, we discuss the possible pathological significance of these intracellular APP fragments and the expected future research directions regarding this thought-provoking problem.

Abstract

In this review we highlight the evidence for an intracellular origin of Abeta (Aβ) amyloid peptides as well as the observations for a pathological accumulation of these peptides in Alzheimer's disease and Down syndrome, as well as in transgenic animal models. We deliberate on the controversy as to whether the intracellular Aβ immunoreactive material is simply an accumulation of unprocessed full length amyloid precursor protein (APP) or a mix of processed APP fragments including Aβ. Finally, we discuss the possible pathological significance of these intracellular APP fragments and the expected future research directions regarding this thought-provoking problem.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute for Regenerative Medicine (IREM)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:22 Jan 2013 12:46
Last Modified:07 Dec 2017 18:15
Publisher:Elsevier
ISSN:0024-3205
Publisher DOI:https://doi.org/10.1016/j.lfs.2012.05.020
PubMed ID:22705309

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