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Assessment of the ochratoxin A production ability of Aspergillus tubingensis


Storari, Michelangelo; Bigler, Laurent; Gessler, Cesare; Broggini, Giovanni A L (2012). Assessment of the ochratoxin A production ability of Aspergillus tubingensis. Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment, 29(9):1450-1454.

Abstract

Aspergillus tubingensis is a black Aspergillus frequently isolated from different agricultural products, including grapes. Conflicting results have been published in recent years about its ability to produce ochratoxin A (OTA), a potent nephrotoxic and carcinogenic mycotoxin. This study re-examined six A. tubingensis strains deposited in international culture collections for OTA production. OTA could not be detected in any A. tubingensis extract using HPLC coupled with a fluorescence detector (FLD), whereas it was easily detected in ochratoxigenic A. niger extracts used as positive control. The same outcome was obtained using LC-MS. The presence of other metabolites with retention times similar to the OTA signal in the A. tubingensis extracts or background noise of the growth media may be reasons for the misinterpretation of the chromatograms obtained by HPLC-FLD.

Abstract

Aspergillus tubingensis is a black Aspergillus frequently isolated from different agricultural products, including grapes. Conflicting results have been published in recent years about its ability to produce ochratoxin A (OTA), a potent nephrotoxic and carcinogenic mycotoxin. This study re-examined six A. tubingensis strains deposited in international culture collections for OTA production. OTA could not be detected in any A. tubingensis extract using HPLC coupled with a fluorescence detector (FLD), whereas it was easily detected in ochratoxigenic A. niger extracts used as positive control. The same outcome was obtained using LC-MS. The presence of other metabolites with retention times similar to the OTA signal in the A. tubingensis extracts or background noise of the growth media may be reasons for the misinterpretation of the chromatograms obtained by HPLC-FLD.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Plant and Microbial Biology
07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:580 Plants (Botany)
540 Chemistry
Uncontrolled Keywords:black aspergilli; grapes; secondary metabolite; mycotoxin
Language:English
Date:18 September 2012
Deposited On:23 Jan 2013 11:23
Last Modified:05 Apr 2016 16:19
Publisher:Taylor & Francis
ISSN:1944-0057
Publisher DOI:https://doi.org/10.1080/19440049.2012.698656
PubMed ID:22827810

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