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Cancer cell adhesion and metastasis. Selectins, integrins and the inhibitory potential of heparins


Bendas, Gerd; Borsig, Lubor (2012). Cancer cell adhesion and metastasis. Selectins, integrins and the inhibitory potential of heparins. International Journal of Cell Biology, 2012:676731.

Abstract

Cell adhesion molecules play a significant role in cancer progression and metastasis. Cell-cell interactions of cancer cells with endothelium determine the metastatic spread. In addition, direct tumor cell-interactions with platelets, leukocytes and soluble components significantly contribute to cancer cell adhesion, extravasation, and the establishment of metastatic lesions.
Clinical evidence indicates that heparin, commonly used for treatment of thromboembolic events in cancer patients, is beneficial for their survival. Preclinical studies confirm that heparin possesses anti-metastatic activities that lead to attenuation of metastasis in various animal models. Heparin contains several biological activities that may affect several steps in metastatic cascade. Here we focus on the role of cellular adhesion receptors in the metastatic cascade and discuss evidence for heparin as an inhibitor of cell adhesion. While P- and L-selectin facilitation of cellular contacts during hematogenous metastasis is being accepted as a potential target of heparin, here we propose that heparin may also interfere with integrin activity and thereby affect cancer progression.
This review summarizes recent findings about potential mechanisms of tumor cell interactions in the vasculature and anti-metastatic activities of heparin.

Abstract

Cell adhesion molecules play a significant role in cancer progression and metastasis. Cell-cell interactions of cancer cells with endothelium determine the metastatic spread. In addition, direct tumor cell-interactions with platelets, leukocytes and soluble components significantly contribute to cancer cell adhesion, extravasation, and the establishment of metastatic lesions.
Clinical evidence indicates that heparin, commonly used for treatment of thromboembolic events in cancer patients, is beneficial for their survival. Preclinical studies confirm that heparin possesses anti-metastatic activities that lead to attenuation of metastasis in various animal models. Heparin contains several biological activities that may affect several steps in metastatic cascade. Here we focus on the role of cellular adhesion receptors in the metastatic cascade and discuss evidence for heparin as an inhibitor of cell adhesion. While P- and L-selectin facilitation of cellular contacts during hematogenous metastasis is being accepted as a potential target of heparin, here we propose that heparin may also interfere with integrin activity and thereby affect cancer progression.
This review summarizes recent findings about potential mechanisms of tumor cell interactions in the vasculature and anti-metastatic activities of heparin.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:February 2012
Deposited On:25 Jan 2013 08:21
Last Modified:09 Dec 2017 01:58
Publisher:Hindawi Publishing Corporation
ISSN:1687-8876
Funders:SNF
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1155/2012/676731
PubMed ID:22505933

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