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Acute febrile respiratory reaction after praziquantel treatment during asymptomatic late form of acute schistosomiasis


Neumayr, Andreas L C; Tschirky, Beatrice; Warren, Ashley; Hatz, Christoph; Blum, Johannes A (2012). Acute febrile respiratory reaction after praziquantel treatment during asymptomatic late form of acute schistosomiasis. Journal of Travel Medicine, 19(4):264-267.

Abstract

Paradoxical reactions (Jarish Herxheimer-like reactions) have been described in patients treated with praziquantel (PZQ) during acute schistosomiasis (infected≤ 3 mo), while PZQ treatment of chronic schistosomiasis is generally considered to be safe. We report an acute febrile reaction with respiratory decompensation following PZQ treatment in a 17-year-old male patient who had no potential (re)exposure to infection for at least 5 months and was therefore considered to have reached the chronic stage of disease. We speculate that the clinical manifestations in our patient constitute a very late paradoxical reaction in an unusually long acute phase of infection.

Abstract

Paradoxical reactions (Jarish Herxheimer-like reactions) have been described in patients treated with praziquantel (PZQ) during acute schistosomiasis (infected≤ 3 mo), while PZQ treatment of chronic schistosomiasis is generally considered to be safe. We report an acute febrile reaction with respiratory decompensation following PZQ treatment in a 17-year-old male patient who had no potential (re)exposure to infection for at least 5 months and was therefore considered to have reached the chronic stage of disease. We speculate that the clinical manifestations in our patient constitute a very late paradoxical reaction in an unusually long acute phase of infection.

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2 citations in Web of Science®
3 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:18 Jan 2013 07:30
Last Modified:05 Apr 2016 16:20
Publisher:Wiley-Blackwell
ISSN:1195-1982
Publisher DOI:https://doi.org/10.1111/j.1708-8305.2012.00626.x
PubMed ID:22776392

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