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Levels of monocyte chemoattractant protein-1 differ from the norm in patients with sudden sensorineural hearing loss.


Haubner, F; Martin, L; Steffens, T; Rohrmeier, C; Strutz, J; Kleinjung, T (2012). Levels of monocyte chemoattractant protein-1 differ from the norm in patients with sudden sensorineural hearing loss. Journal of Hearing Science, 2(1):36-40.

Abstract

Background: The aim of this study was to evaluate the role of cytokines and soluble adhesion molecules in patients with sudden sensorineural hearing loss (SSNHL) with respect to their pure-tone audiometry values.

Material and Methods: This study analyses blood samples of 51 patients with SSNHL. Serum levels of ICAM-1, VCAM-1,
E-selectin, IL-6, IL-8, and MCP-1 were evaluated by ELISA. Pure-tone audiometry data were compared before and after a systemic steroid treatment regimen. The subjects with SSNHL were compared to a control group of 44 patients with normal hearing and matching age and gender. The data complete our previous data collection.

Results: There is trend toward suppressed levels of MCP-1 in sera of SSNHL patients. There were no statistically significant differences concerning ICAM-1, VCAM-1, E-selectin, IL-6, IL-8, and MCP-1 between SSNHL patients and controls. Puretone audiometry of the SSNHL group showed a significant improvement in hearing after systemic steroid therapy and a median follow-up of 4 months.

Conclusions: Further prospective studies are necessary to prove the role of MCP-1 and other cytokines in SSNHL in order to develop adequate treatment regimens.

Abstract

Background: The aim of this study was to evaluate the role of cytokines and soluble adhesion molecules in patients with sudden sensorineural hearing loss (SSNHL) with respect to their pure-tone audiometry values.

Material and Methods: This study analyses blood samples of 51 patients with SSNHL. Serum levels of ICAM-1, VCAM-1,
E-selectin, IL-6, IL-8, and MCP-1 were evaluated by ELISA. Pure-tone audiometry data were compared before and after a systemic steroid treatment regimen. The subjects with SSNHL were compared to a control group of 44 patients with normal hearing and matching age and gender. The data complete our previous data collection.

Results: There is trend toward suppressed levels of MCP-1 in sera of SSNHL patients. There were no statistically significant differences concerning ICAM-1, VCAM-1, E-selectin, IL-6, IL-8, and MCP-1 between SSNHL patients and controls. Puretone audiometry of the SSNHL group showed a significant improvement in hearing after systemic steroid therapy and a median follow-up of 4 months.

Conclusions: Further prospective studies are necessary to prove the role of MCP-1 and other cytokines in SSNHL in order to develop adequate treatment regimens.

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Additional indexing

Item Type:Journal Article, not refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:14 Jan 2013 11:46
Last Modified:05 Apr 2016 16:20
Publisher:International Scientific Literature, Inc.
ISSN:2083-389X

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