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Pretreatment thrombocytosis: a prognostic marker for oral squamous cell carcinoma?


Kargus, Steffen; Weber, Franz E; Luebbers, Heinz T; Zemann, Wolfgang; Graetz, Klaus W; Kruse, Astrid L (2012). Pretreatment thrombocytosis: a prognostic marker for oral squamous cell carcinoma? Oral and Maxillofacial Surgery, 16(2):197-200.

Abstract

PURPOSE: Thrombocytosis associated with poorer prognoses seems to be a frequent preoperative finding in different kind of cancers. The aim of the present study was to evaluate whether thrombocytosis can be used as a prognostic marker for oral squamous cell carcinoma (SCC).
METHODS: Altogether, 288 patients with oral SCC were considered, as well as all platelet counts between 1 and 5 days prior to surgical treatment, recurrence rate, and lymph node metastasis. The minimum follow-up time was 12 months.
RESULTS: The mean preoperative thrombocyte score of the patients who received surgery was 259.55 ± 83.8 Tsd/μl; 273 out of 288 patients were in the normal thrombocyte range, and 12 had a thrombocytosis. From 51 patients with recurrence, three were in the thrombocytosis group, and 45 patients with recurrence were in the normal thrombocyte range.
CONCLUSION: The present results do not confirm that thrombocytosis can be seen as marker for poor tumor prognosis.

Abstract

PURPOSE: Thrombocytosis associated with poorer prognoses seems to be a frequent preoperative finding in different kind of cancers. The aim of the present study was to evaluate whether thrombocytosis can be used as a prognostic marker for oral squamous cell carcinoma (SCC).
METHODS: Altogether, 288 patients with oral SCC were considered, as well as all platelet counts between 1 and 5 days prior to surgical treatment, recurrence rate, and lymph node metastasis. The minimum follow-up time was 12 months.
RESULTS: The mean preoperative thrombocyte score of the patients who received surgery was 259.55 ± 83.8 Tsd/μl; 273 out of 288 patients were in the normal thrombocyte range, and 12 had a thrombocytosis. From 51 patients with recurrence, three were in the thrombocytosis group, and 45 patients with recurrence were in the normal thrombocyte range.
CONCLUSION: The present results do not confirm that thrombocytosis can be seen as marker for poor tumor prognosis.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Clinic for Cranio-Maxillofacial Surgery
04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Research
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:28 Jan 2013 08:31
Last Modified:05 Apr 2016 16:20
Publisher:Springer
ISSN:1865-1550
Publisher DOI:https://doi.org/10.1007/s10006-011-0305-6
PubMed ID:22108700

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