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Effects of doxapram, prethcamide and lobeline on spirometric, blood gas and acid-base variables in healthy newborn calves


Bleul, U; Bylang, T (2012). Effects of doxapram, prethcamide and lobeline on spirometric, blood gas and acid-base variables in healthy newborn calves. Veterinary Journal, 194(2):240-246.

Abstract

A number of drugs have been used to treat asphyxia in new-born calves and the aim of the current study was to investigate the effect of commonly-used stimulant drugs on ventilation, arterial blood gas and acid base variables. A group (n = 18) of new-born (3–15 h old) calves were treated in a randomised sequence with doxapram (40 mg, IV), lobeline (5 mg, IV) or prethcamide (5 mL, consisting of 375 mg crotethamide and 375 mg cropropamide, buccally). Blood and spirometric measurements, using an ultrasonic spirometer, were collected prior to and 1, 5, 15, 30, 60, 90 min after administration of each drug.
Doxapram caused a significant increase in the respiratory rate, peak inspiratory and expiratory flow and minute volume (Vmin) during the 90-min post-treatment study period, although maximum values occurred 1 min after treatment. The Vmin increased from 13.8 ± 5.0 L to 28.5 ± 12.3 L. Prethcamide, but not lobeline, also caused significant increases in inspiratory and expiratory volumes. The effects of doxapram on ventilation were accompanied by an increase in arterial partial pressure of oxygen (PaO2) (77.7 ± 18.8 mm Hg to 93.2 ± 23.7 mm Hg), a decrease in arterial partial pressure of carbon dioxide (PaCO2) (42.6 ± 4.9 mm Hg to 33.1 ± 6.6 mm Hg), a significant increase in pH and a decrease in bicarbonate concentration and base excess 1 min after treatment. Prethcamide caused a gradual increase in PaO2 and decrease in PaCO2 over 90 min, whereas lobeline had no measurable effect on the investigated variables. Of the three treatments, only doxapram had a distinct stimulatory effect on respiration in healthy neonatal calves and may therefore be useful in the treatment of calf asphyxia.

Abstract

A number of drugs have been used to treat asphyxia in new-born calves and the aim of the current study was to investigate the effect of commonly-used stimulant drugs on ventilation, arterial blood gas and acid base variables. A group (n = 18) of new-born (3–15 h old) calves were treated in a randomised sequence with doxapram (40 mg, IV), lobeline (5 mg, IV) or prethcamide (5 mL, consisting of 375 mg crotethamide and 375 mg cropropamide, buccally). Blood and spirometric measurements, using an ultrasonic spirometer, were collected prior to and 1, 5, 15, 30, 60, 90 min after administration of each drug.
Doxapram caused a significant increase in the respiratory rate, peak inspiratory and expiratory flow and minute volume (Vmin) during the 90-min post-treatment study period, although maximum values occurred 1 min after treatment. The Vmin increased from 13.8 ± 5.0 L to 28.5 ± 12.3 L. Prethcamide, but not lobeline, also caused significant increases in inspiratory and expiratory volumes. The effects of doxapram on ventilation were accompanied by an increase in arterial partial pressure of oxygen (PaO2) (77.7 ± 18.8 mm Hg to 93.2 ± 23.7 mm Hg), a decrease in arterial partial pressure of carbon dioxide (PaCO2) (42.6 ± 4.9 mm Hg to 33.1 ± 6.6 mm Hg), a significant increase in pH and a decrease in bicarbonate concentration and base excess 1 min after treatment. Prethcamide caused a gradual increase in PaO2 and decrease in PaCO2 over 90 min, whereas lobeline had no measurable effect on the investigated variables. Of the three treatments, only doxapram had a distinct stimulatory effect on respiration in healthy neonatal calves and may therefore be useful in the treatment of calf asphyxia.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Language:English
Date:2012
Deposited On:29 Jan 2013 12:52
Last Modified:21 Nov 2017 16:24
Publisher:Elsevier
ISSN:1090-0233
Publisher DOI:https://doi.org/10.1016/j.tvjl.2012.04.007
PubMed ID:22609153

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