Header

UZH-Logo

Maintenance Infos

Hypodense regions in unenhanced CT identify nonviable myocardium: validation versus 18F-FDG PET


Fuchs, Tobias A; Ghadri, Jelena R; Stehli, Julia; Gebhard, Catherine; Kazakauskaite, Egle; Klaeser, Bernd; Gaemperli, Oliver; Fiechter, Michael; Kaufmann, Philipp A (2012). Hypodense regions in unenhanced CT identify nonviable myocardium: validation versus 18F-FDG PET. European Journal of Nuclear Medicine and Molecular Imaging, 39(12):1920-1926.

Abstract

PURPOSE: The aim of the present study was to evaluate the accuracy of hypodense regions in non-contrast-enhanced cardiac computed tomography (unenhanced CT) to identify nonviable myocardial scar tissue.
METHODS: Hypodense areas were visually identified in unenhanced CT of 80 patients in the left ventricular anterior, apical, septal, lateral and inferior myocardium and CT density was measured in Hounsfield units (HU). Findings were compared to (18)F-fluorodeoxyglucose uptake by positron emission tomography (FDG PET), which served as the standard of reference to distinguish scar (<50 % FDG uptake) from viable tissue (≥50 % uptake).
RESULTS: Visually detected hypodense regions demonstrated a sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 74, 97, 84 and 94 %, respectively. A receiver-operating characteristic (ROC) curve analysis revealed a cutoff value of mean HU at <28.8 for predicting scar tissue with an area under the curve of 0.93 yielding a sensitivity, specificity, PPV and NPV of 94, 90, 67 and 99 %, respectively.
CONCLUSION: Hypodense regions in unenhanced cardiac CT scans allow accurate identification of nonviable myocardial scar tissue.

Abstract

PURPOSE: The aim of the present study was to evaluate the accuracy of hypodense regions in non-contrast-enhanced cardiac computed tomography (unenhanced CT) to identify nonviable myocardial scar tissue.
METHODS: Hypodense areas were visually identified in unenhanced CT of 80 patients in the left ventricular anterior, apical, septal, lateral and inferior myocardium and CT density was measured in Hounsfield units (HU). Findings were compared to (18)F-fluorodeoxyglucose uptake by positron emission tomography (FDG PET), which served as the standard of reference to distinguish scar (<50 % FDG uptake) from viable tissue (≥50 % uptake).
RESULTS: Visually detected hypodense regions demonstrated a sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 74, 97, 84 and 94 %, respectively. A receiver-operating characteristic (ROC) curve analysis revealed a cutoff value of mean HU at <28.8 for predicting scar tissue with an area under the curve of 0.93 yielding a sensitivity, specificity, PPV and NPV of 94, 90, 67 and 99 %, respectively.
CONCLUSION: Hypodense regions in unenhanced cardiac CT scans allow accurate identification of nonviable myocardial scar tissue.

Statistics

Citations

2 citations in Web of Science®
2 citations in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:04 Feb 2013 10:24
Last Modified:05 Apr 2016 16:22
Publisher:Springer
ISSN:1619-7070
Publisher DOI:https://doi.org/10.1007/s00259-012-2212-y
PubMed ID:22926710

Download

Full text not available from this repository.
View at publisher