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Synthesis of DNA interstrand crosslinks using a photocaged nucleobase


Hentschel, Sarah; Alzeer, Jawad; Angelov, Todor; Schärer, Orlando D; Luedtke, Nathan W (2012). Synthesis of DNA interstrand crosslinks using a photocaged nucleobase. Angewandte Chemie Internationale Edition, 51(14):3466-3469.

Abstract

BCNU is a chemotherapy drug that generates an ethylene bridge between N1 of deoxyguanosine and N3 of deoxycytidine. No synthesis of a DNA containing this moiety has been reported until now. A new strategy uses a photocaged nucleobase that, when released, generates a highly reactive intermediate which cross-links the opposing DNA strand in a manner analogous to BCNU.

Abstract

BCNU is a chemotherapy drug that generates an ethylene bridge between N1 of deoxyguanosine and N3 of deoxycytidine. No synthesis of a DNA containing this moiety has been reported until now. A new strategy uses a photocaged nucleobase that, when released, generates a highly reactive intermediate which cross-links the opposing DNA strand in a manner analogous to BCNU.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:2 April 2012
Deposited On:05 Feb 2013 12:28
Last Modified:16 Dec 2016 11:37
Publisher:Wiley-VCH Verlag
ISSN:1433-7851
Publisher DOI:https://doi.org/10.1002/anie.201108018
PubMed ID:22344895

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