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Pharmakogenetik: Relevante Aspekte für den praktizierenden Tierarzt


Jud Schefer, R S; Paine Kuhn, C; Demuth, D C (2012). Pharmakogenetik: Relevante Aspekte für den praktizierenden Tierarzt. Schweizer Archiv für Tierheilkunde, 154(12):521-527.

Abstract

Pharmacogenetics is the study of genetic determinants of different responses to drug therapy and deals with differences in metabolic pathways and therapeutic effects as well as adverse reactions. A common genetic defect found in veterinary medicine is the MDR1 mutation occurring in Collies and related breeds that leads to an altered P-glycoprotein. Genetic mutations of enzymes (cytochrome P450, thiopurine s-methyltransferase, n-acetyltransferase, UDP-glucuronyltransferase, plasma esterase or sulfotransferase), which are responsible for the metabolism of drugs, are found as well. A decreased functional level of these enzymes can lead to an increased plasma concentration of the drug with a consequent relative overdose.

Abstract

Pharmacogenetics is the study of genetic determinants of different responses to drug therapy and deals with differences in metabolic pathways and therapeutic effects as well as adverse reactions. A common genetic defect found in veterinary medicine is the MDR1 mutation occurring in Collies and related breeds that leads to an altered P-glycoprotein. Genetic mutations of enzymes (cytochrome P450, thiopurine s-methyltransferase, n-acetyltransferase, UDP-glucuronyltransferase, plasma esterase or sulfotransferase), which are responsible for the metabolism of drugs, are found as well. A decreased functional level of these enzymes can lead to an increased plasma concentration of the drug with a consequent relative overdose.

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Additional indexing

Other titles:Pharmacogenetics: Relevant aspects for the practicing veterinarian
Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
Language:German
Date:2012
Deposited On:28 Jan 2013 08:32
Last Modified:05 Apr 2016 16:25
Publisher:Hans Huber
ISSN:0036-7281
Publisher DOI:https://doi.org/10.1024/0036-7281/a000401
PubMed ID:23188764

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Language: German
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